肠促胰素类药物在2型糖尿病治疗中的作用
摘要
肠促胰素类药物,是近年来治疗领域的热点。本文将主要介绍其在2型糖尿病临床治疗中的作用。1964年Elriek等指出,在相同葡萄糖数量情况下,正常人口服葡萄糖刺激的胰岛素分泌量(19%~61%的胰岛素分泌来自GLP-1的作用)明显超过静脉葡萄糖所引起的胰岛素分泌量,并将这种现象称为“肠促胰素”效应。从此,肠促胰素开始引起人们的关注。
出处
《实用糖尿病杂志》
2013年第3期6-9,共4页
Journal of Practical Diabetology
参考文献24
-
1Elrick H, Stimmler L, Hlad CJ, et al. Plasma insulin response to oral and intravenous glucose administration, J Clin Endocduol Metab 1964 ;24:1076 - 1082.
-
2Holz GG 4th, KUhtreiber WM, Habener JF. Pancreatic beta- cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7 - 37). Nature 1993 ;361:362 - 365.
-
3Anini Y, Brubaker PL. Muscarinic receptors control glucagon- like peptide 1 secretion by human endocrine L cells. Endocrinology 2003 ; 144:3244 - 3250.
-
4Herrmann C, Goke R, Richter G,et al. Glucagon-like peptide- 1 and glucose-dependent insulin-releasing polypetide plasma levels in response to nutrients. Digestion 1995;56:117 - 126.
-
5De Leon DD, Crutehlow MF, Ham JY, et al. Role of gluca- gon-like peptide-1 in the pathogenesis and treatment of diabetes melli- tus. Int J Biochem Cell Biol 2006 ;38:845 - 859.
-
6Knop FK. Reduced incretin effect in type 2 diabetes: causeor consequence of the diabetic state?. Diabetes 2007 ;56 : 1951 - 1959.
-
7Nauck MA,Heimesaat MM,Holst JJ. Preserved incretin activ- ity of glucagon-like peptited-1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 dibetes meUitus. Clin Invest 1993;91:301 -307.
-
8Tort-Nielsen MB, Damholt MB, Madsbad S, et al. Determi- nants of the impaired secretion of glucagon-like peptide-1 in type 2 di- abetic patients. J Clin Endocrinol Metab 2001 ;86:3717 -3723.
-
9Baggio LL, Drucker DJ. Biology of Incretins: GLP-1 and GIP. Gastroenterology 2007;132:2131 -2157.
-
10Kim SJ,Winter K, Nian C. GIP stimulation of pancreatic beta- cell survival is dependent upon phosphatidylinositol 3-kinase (PI3-K)/ protein kinase B ( PKB ) signaling, inactivation of the forkhead tran- scription factor Foxol and downregulation of bax expression. Bio Chem 2005 ;280:22297 - 22307.
二级参考文献4
-
1Ahmad SR, Swann J. Exenatide and rare adverse events[J]. N Engl J of Med, 2008, 358: 1970-1971.
-
2FDA. Drug information for healthcare professionals exenatide (marketed as Byetta) [ EB/OL]. 2008-08-18. http://www, fda. gov/cder/drug/InfoSheets/HCP/exenatide2008 HCP. htm.
-
3Kawji H, John K, Alarickal J. Acute necrotizing pancreatitis in a patient taking exenatide (Byetta) [ C]. 90th Annual Meeting of the Endocrine Society. 2008 : 1-322.
-
4FDA. Drug safety newsletter for exenatide ( marketed as Byetta) : acute pancreatitis[ EB/OL]. 2008, 1 (2). http://www, fda. gov/cder/dsn/2008 _winter/2008_winter. pdf.
-
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-
2薛小琴,杨向军.原发性高血压左心室肥厚与心律失常的关系探讨[J].浙江临床医学,2014,16(8):1260-1261. 被引量:3
-
3曾建红,曾军,李越利,梁健欣.低分子肝素在慢性阻塞性肺疾病急性加重期合并呼吸衰竭的治疗作用[J].中国医药科学,2016,6(14):46-48. 被引量:14
-
4李社莉,于俊霞,吕双燕.延安市居民高血压患病及与代谢疾病关系[J].中国公共卫生,2012,28(1):94-95. 被引量:6
-
5赵红梅,贾桂香,崔广伟.心理护理对原发性高血压患者干预效果探讨[J].中国实用医药,2015,10(10):235-236. 被引量:4
-
6赵幼安,褚衍六.重视非酒精性脂肪性肝病的基础和临床研究[J].内科理论与实践,2008,3(1):5-7. 被引量:1
-
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-
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-
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-
10王东兴.β_2-微球蛋白测定在糖尿病早期肾损害中的应用探讨[J].中国社区医师(医学专业),2010,12(5):124-125.