摘要
目的:观察铝碳酸镁联合雷贝拉唑治疗胃食管反流性咽喉炎的临床疗效。方法:选择胃食管反流性咽喉炎患者400例,按患者就诊日期的单双号均分为观察组和对照组。两组患者均给予常规清咽、利喉、抗感染治疗。观察组患者在此基础上加用铝碳酸镁1.0g,tid+雷贝拉唑20mg,bid。两组疗程均为4～6周。比较两组患者的临床疗效、食管pH<4时间的百分比、DeMeester评分及临床症状总分。结果:与治疗前比较,观察组治疗后第一通道、第二通道pH<4时间的百分比及DeMeester评分差异均有统计学意义(P<0.01),而对照组差异无统计学意义(P>0.05)。治疗后两组间临床症状总分和总有效率比较,观察组均显著优于对照组,差异有统计学意义(P<0.01)。两组患者均未见明显不良反应发生。结论:铝碳酸镁片联合雷贝拉唑治疗胃食管返流性咽喉炎疗效和安全性较好,且能有效缓解患者的临床症状。
OBJECTIVE：To observe the clinical efficacy of hydrotalcite combined with rabeprazole in the treatment of gastroesophageal reflux laryngitis.METHODS：400 patients with gastroesophageal reflux laryngitis during Oct.2008-Oct.2012 in our hospital were divided into study group and control group according to single or double day.Control group only received conventional therapy.On the basis of conventional therapy,study group was additionally given hydrotalcite 1.0 g,tid combined with rabeprazole 20 mg,bid for 4-6 weeks.The clinical efficacies,the percentage of pH4,De Meester score and clinical symptom score were compared between 2 groups.RESULTS：The percentage of first channel pH4 and second channel pH4 and De Meester score in study group had statistical significance before and after treatment（P0.01）,and there was no significant difference in control group（P0.05）.After treatment,clinical symptom scores and total effective rate of study group were significantly better than those of control group,there was statistical significance（P0.01）.No significant adverse drug reaction was found in 2 groups.CONCLUSIONS：Hydrotalcite tablets combined with rabeprazole therapy for gastroesophageal reflux laryngitis can improve therapeutic efficacy and relieve symptoms.
出处
《中国药房》
CAS
CSCD
2013年第32期3013-3015,共3页
China Pharmacy
关键词
胃食管反流
咽喉炎
铝碳酸镁片
雷贝拉唑
临床症状评分
Gastroesophageal reflux
Laryngitis
Hydrotalcite tablets
Rabeprazole
Clinical sysptom score
