摘要
目的 :探讨急性脑梗死 ( ACI)与血浆内皮素 ( ET)、降钙素基因相关肽 ( CGRP)的关系。方法 :采用放免法测定脑梗死组 45例、正常对照组 47例血浆 ET、CGRP水平。结果 :ACI组血浆 ET为 ( 10 8.80± 38.77) ng/ L,显著高于正常对照组( 5 1.19± 16 .75 ) ng/ L,P <0 .0 1。ACI组血浆 CGRP为 ( 2 3.72± 12 .5 5 ) ng/ L,显著低于正常对照组 ( 36 .89± 17.30 ) ng/ L,P <0 .0 1。ACI伴高血压者 ET显著高于不伴高血压者 ,而 CGRP显著低于不伴高血压者 ,P <0 .0 5。结论 :ACI患者 ET较正常人升高 ,而 CGRP较正常人降低 ,ET和
Objective:To investigate the relationship between plasma levels of endothelin (ET) and calcitonin generelated peptide (CGRP) and acute cerebral infarction (ACI).Methods:Plasma levels of ET and CGRP were measured by radioimmunoassay in 45 with ACI and 47 normal subjectsResults:The plasma levels of ET in ACI group (10880±3877)ng/L were significantly higher than those of the normal subjects (5119 ±1675)ng/L,P<001The plasma levels of CGRP in ACI group (2372 ±1255)ng/L were significantly lower than those of the normal subjects (3689 ±1730)ng/L,P<001The plasma levers of ET in ACI with hypertension were significantly higher than those of without hypertension,but CGRP were significantly lower than those of without hypertensionConclusion:The plasma levels of ET in ACI were higher and CGRP were lower than those of normal subjects,those changes may play an important role in the pathogenesis of stroke
出处
《广西医科大学学报》
CAS
2000年第3期422-423,共2页
Journal of Guangxi Medical University
关键词
急性脑梗死
内皮素
降钙素基因相关肽
acute cerebral infarction
endothelin
calcitonin gene-related peptide
