摘要
目的:探讨甲状腺自身抗体(ATA)与复发性自然流产(RSA)的关系,为RSA的诊断治疗提供相关的科学依据。方法:采用电化学发光法对120例RSA患者血清进行抗甲状腺过氧化酶抗体(TPO-Ab)和抗甲状腺球蛋白抗体(TG-Ab)的检测,并以60名健康育龄妇女为对照。结果:RSA患者中ATA总阳性率28.3%,明显高于对照组8.3%,RSA组中TPO-Ab和TG-Ab的阳性率分别为20.8%和18.3%,均显著高于对照组的6.7%和5.0%。早期流产组中的ATA总阳性率36.1%,与晚期流产组的16.7%比较P<0.05;TPO-Ab和TG-Ab的阳性率分别为26.4%和23.6%,均显著高于晚期流产组的12.5%和10.4%。2次流产和≥3次流产组患者ATA的阳性率分别为31.9%和22.9%(P>0.05)。结论:孕妇ATA的存在与反复自然流产密切相关,ATA可作为早期反复自然流产的监测指标。
Objective：To study the relationship between thyroid autoantibodies（ATA）and recurrent spontaneous abortion（RSA）,provides scientific basis for diagnosis and treatment.Method：Serum anti-thyroid peroxidase antibodies（TPO-Ab）and thyroglobulin antibody（TG-Ab）were detected by electrochemiluminescence immunoassay in 120 cases of RSA patients,and 60 healthy women of childbearing age for control.Result：ATA positive rate（28.3%）in RSA patients was higher than that（8.3%）in control group.TPO-Ab and TG-Ab positive rates were 20.8% and 18.3% in respectively,which were significantly higher than those in normal control group（6.7% and 5.0% in respectively）.The total positive rate of ATA in early RSA group（〈12 weeks）was 36.1%,and late RSA group（≥12 weeks）16.7%,the statistical difference was significant.TPO-Ab and TG-Ab positive rates were 26.4% and 23.6%,which were significantly higher than those of late abortion group（12.5% and 10.4% respectively）.ATA positive rates in 2 times of abortion and ≥3 abortions group were 31.9% and 22.9% respectively,there was no statistical difference between the two groups.Conclusion：ATA in pregnant women and RSA is closely related,ATA can be used as the monitoring index of early RSA.
出处
《临床血液学杂志（输血与检验）》
CAS
2013年第4期557-558,共2页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
甲状腺自身抗体
反复自然流产
TPO-AB
TG-AB
thyroid autoantibodies
recurrent spontaneous abortion
anti-thyroid peroxidase antibodies（TPO-Ab）
thyroglobulin antibody（TG-Ab）
