摘要
目的 观察A型肉毒毒素治疗偏侧面肌痉挛、眼肌痉挛、Meige综合征 (睑痉挛 -口颌肌张力障碍综合征 )及痉挛性斜颈的疗效。方法 用A型肉毒毒素对 6 4例肌张力障碍患者 (5 1例偏侧面肌痉挛、10例眼睑痉挛、1例Meige综合征、2例痉挛性斜颈 )行面部肌肉局部多点注射 ,分析其治疗效果。结果 5 1例偏侧面肌痉挛者 ,完全缓解 2 0例 (4 0 % ) ,明显缓解 30例 (5 9% ) ,1例无效 ;10例眼睑痉挛者 ,5例完全缓解 ,4例明显缓解 ,1例无效 ;1例Meige综合征部分缓解 ;2例痉挛性斜颈者 ,1例明显缓解 ,1例部分缓解 ;总有效率达 97%。起效时间数小时至 7天 ,缓解时间 3～ 7个月。局部副反应轻微、短暂 ,无全身反应及过敏反应。结论 A型肉毒毒素局部肌肉注射可有效控制局部肌张力过高 ,改善患者的异常面容和姿势。
Objective To study the efficacy of botulinum A toxin injection for the treatment of hemifacial spasm, blepharospasm, Meige′s syndrome and spasmodic torticollis. Methods A total of 64 patients, (51 patients with hemifacial spasm, 10 with blepharospasm, 1 Meige′s syndrome and 2 with spasmodic torticollis) were evaluated on therapeutic efficacy of multifocal facial injection. Results Of the 51 patients with hemifacial spasm, 20(40%) patients were completely relieved, 30(59%) remarkable relieved, and one didn′t have improvement; of 10 patients with blepharospasm 4 were remarkably relieved, and 1 had no improvement; one patient with Meige′s syndrome was partial relieved, of the 2 patients with spasmodic torticollis 1 remarkably relieved, the other partial relieved; 97% of the patients experienced relief from spasm. Clinical observation showed marked improvement in symptoms from a few hours to the third day after injection and lasted about 3 to 7 months. The local side effects were transient and mild, no systemic adverse and allergic reactions were noted. Conclusion Botulinum A toxin local injection may control hyperdystonia effectively, and ameliorate patients′ abnormal face contour and posture.
出处
《实用美容整形外科杂志》
2000年第5期236-238,共3页
Journal of Practical Aesthetic and Plastic Surgery
关键词
A型肉毒毒素
眼睑痉挛
面肌痉挛
MEIGE综合征
Botulinum toxin
Blepharospasm
Hemifacial spasm
Meige′s syndrome
Spasmodic torticollis
