摘要
胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)在人类多种组织细胞中广泛存在,在受体和结合蛋白的介导下,通过自分泌、旁分泌和内分泌的方式作用于靶器官,促进细胞的生长和分化。IGF-1R是一种跨膜酪氨酸蛋白激酶受体,其TK区的C末端多位点酪氨酸与肿瘤细胞的发生、迁徙、侵袭、转移密切相关。研究表明,IGF-1在肺癌组织中呈高表达,且与肺癌的转化和恶性进展有关,靶向IGF-1R的信号通路可以有效抑制肿瘤细胞的增殖、转移和侵袭。本文旨在对IGF-1及其受体在肺癌领域的研究进展进行综述。
lrtsulin-like growth factor-1(IGF-1)widespread in a variety of human tissue cells,receptors and binding pro-teins mediated through paracrine,autocrine,and endocrine role in the target organ,the promotion of cell growth and differentia-tion.IGF-1R is a trammembrane protein tyrosine kinase receptor,its C-Terminal tyrosine of the TK area,migration,invasion and metastasis of tumor cells are closely related.A growing number of studies confirmed that,IGF-1 expresses in lung cancer and is associated with transformation and malignant progression of lung cancer,target IGF-1K signaling pathway can effectively in-hibit tumor cell proliferation and metastasis and invasion.This article is intended to elaborate IGF-1 and its receptors in lung cancer research and a summary of the progress made in the field.
作者
陈丽
贾晓民
赵杰
杜永亮
Chen Li;Jia Xiaomin;Zhao Jie;Du Yongiang(The Second Affiliated Hospital of Respiratory Medicine,Xuzhou Medical College,Xuzhou,Jiangsu,221006,China)
出处
《肿瘤药学》
CAS
2013年第4期246-249,共4页
Anti-Tumor Pharmacy
基金
徐州市科技局2011科研项目资助(XF11C102)
关键词
肺癌
胰岛素样生长因子
受体
靶向治疗
Lung cancer
Insulin-like growth factor-1
Target therapy
Receptors
