摘要
目的研究人β防御素-2(HBD-2)在幽门螺杆菌(H.pylori)相关胃黏膜相关淋巴组织(MALT)淋巴瘤患者胃黏膜中的表达情况,探讨HBD-2在胃MALT淋巴瘤中的作用。方法收集40例在根除治疗前H.pylor(i+)且根除治疗后H.pylori为(-)的胃MALT淋巴瘤患者的胃黏膜组织作为HP组,同时收集36例H.pylor(i-)的慢性浅表性胃炎患者胃黏膜组织作为对照组,用免疫组化法检测HBD-2的表达情况。结果 HBD-2在H.pylori相关胃MALT淋巴瘤中的表达水平高于对照组(P<0.01);根除H.pylori治疗后,HP组HBD-2表达水平降低(P<0.01);且HBD-2在H.pylori相关胃MALT淋巴瘤间质细胞的表达水平高于淋巴瘤细胞(P<0.01);HBD-2在淋巴瘤细胞中无表达。结论 HBD-2可能参与了H.pylori相关胃MALT淋巴瘤的发病过程;但是否具有抗肿瘤作用尚不明确。
Objective To investigate the expression of human[3-defensin 2 （HBD-2） in gastric mucosa of Helico- bacter pylori （H. pylori） associated gastric mucosa-associated lymphoid tissue （MALT） lymphoma, and the role of HBD-2 in gastric MALT lymphoma. Methods Forty gastric mucosa specimens from patients with tt. pylori associated gastric MALT lymphoma were collected. And 36 gastric mucosa specimens from chronic superficial gastritis without H. pylori infection were included as control group. The expression of HBD-2 was detected by immunohistochemistry staining. Results The ex- pression of HBD-2 was significantly higher in H. pylori associated gastric MALT lymphoma than that of control group. （P 〈 0.01）. The expression of HBD-2 was significantly decreased after the eradication of 11. pylori （P 〈 0.01）. The expression of HBD-2 was significantly higher in H. pylori associated gastric MALT lymphoma than that of lymphoma cells （P 〈 0.01）. There was no expression of HBD-2 in lymphoma cells. Conclusion HBD-2 is possibly involved in the pathogenesis of H. pylori associated gastric MALT lymphoma. But whether it has anti-tumor effect is not clear.
出处
《天津医药》
CAS
北大核心
2013年第8期756-758,共3页
Tianjin Medical Journal
关键词
淋巴瘤
B细胞
边缘区
螺杆菌
幽门
Β防御素
胃肿瘤
胃MALT淋巴瘤
lymphoma,B-cell,marginal zone
helicobacter pylori
beta-defensins
stomach neoplasms
gastric MALT lymphoma
