摘要
越来越多的学者认为骨坏死疾病的发生与软骨细胞代谢异常有关,而Wnt/β-catenin信号通路中β-catenin的激活能促进软骨细胞分化,同时也能促进软骨分化中的细胞死亡。因此暗示该通路能够通过调节软骨代谢影响骨坏死疾病的发生发展。其次,软骨细胞特异性β-catenin基因条件敲除小鼠模型的成功建立,有助于阐明Wnt/β-catenin信号通路调节软骨代谢的作用机制,为骨坏死疾病的病机阐述以及针对性治疗提供支持。本文就Wnt/β-catenin信号通路、软骨代谢与骨坏死三者间的关系展开综述。
More and more scholars agreed with the viewpoint that osteonecrosis relates with the metabolic activity of chondrocyte. Moreover,the activation of β-catenin among Wnt/β-catenin signal pathway can promote differentiation of chondrocyte and can promote differentiated cell death. So it suggests that this signal pathway should have an effect to occurrence and development of osteonecrosis by regulating the metabolic activity of chondrocyte. Through the establishment of conditional β-catenin knockout mice,it is helpful to understand the pathogenesis of Wnt/β-catenin signal pathway regulating cartilage metabolism. By the way we can understand the pathogenesis of osteonecrosis and give a targeted treatment to the disease. This article reviewed the relationship of three aspects of Wnt/β-catenin signal pathway,cartilage metabolism and osteonecrosis.
出处
《中国骨伤》
CAS
2013年第7期613-616,共4页
China Journal of Orthopaedics and Traumatology
基金
浙江省自然基金(编号:LZ12H27001)~~
