摘要
目的:应用Meta分析法系统评价中西医结合治疗慢性萎缩性胃炎(chronic atrophy gastritis,CAG)的疗效.方法:系统检索中国知网、万方、维普和Pubmed、Web of science、Embase、Clinical Trials.gov、OVID和Cochran Library数据(截止2013-01)中比较中西医结合与单纯西医治疗CAG的随机对照研究(randomized clinical trial,RCT),对纳入的RCT的研究结果进行合并.结果:共纳入10项研究,1039例CAG患者,对纳入文献进行异质性检验得P=0.99;I2=0%,表明研究数据具有同质性,当采用固定效应模型.此外,合并效应OR=5.32,95%CI:3.59-7.88);合并效应量的检验Z=8.34;P<0.00001,显示中西医结合治疗与单纯西医治疗之间在临床表现和病理改善的总体有效率有统计学差异.结论:中西医结合治疗慢性萎缩性胃炎疗效优于单纯西医治疗.
AIM：To systematically assess the efficacy of combination of Chinese and Western medicine in the treatment of chronic atrophic gastritis（CAG）.METHODS：Randomized controlled trials（RCTs） that compared the efficacy of combination of Chinese and Western medicine versus Western medicine treatment alone in the treatment of CAG were retrieved from CNKI,Wanfang Database,China Scientific Journal Database by VIP,PubMed,Web of Science,Embase,Clinical Trials.Gov,OVID and Cochran Library.Outcomes of included RCTs were combined by using metaanalysis.RESULTS：Ten studies involving 1039 CAG patients were included.A test for homogeneity of the studies included（P = 0.99;I2 = 0%） indicated that the data had homogeneity,and the fixed effect model was therefore used.The amount of pooled effects（OR = 5.32,95%CI：3.59-7.88,Z = 8.34;P 0.00001） showed statistical difference in the improvement of clinical symptoms and pathological examination results between the combination group and Western medicine group.CONCLUSION：Combination of TCM and Western medicine shows obvious advantages in the treatment of CAG compared with Western medicine alone.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第20期1982-1986,共5页
World Chinese Journal of Digestology
基金
江苏省中医药局课题基金资助项目
No.JD11040~~
关键词
慢性萎缩性胃炎
中西医结合治疗
中医药
META分析
Chronic atrophic gastritis
Combination of Chinese and Western medicine
Traditional Chinese medicine
Meta-analysis
