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左西孟旦治疗中重度心力衰竭的疗效 被引量:3

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摘要 随着老龄化社会的到来,心力衰竭的发病率明显增高,心力衰竭已成为老年人患病和死亡的主要原因之一。在我国治疗心力衰竭的药物包括正性肌力药、利尿剂、血管扩张剂、血管紧张素转换酶抑制剂、β2受体阻滞剂等。左西孟旦选择性与心肌肌钙蛋白C的N-末端结合,稳定心肌钙键,增强心肌肌钙蛋白C对钙离子的敏感性,增强心肌收缩力,但不提高细胞内的钙离子浓度,对心率影响较小,
出处 《江苏医药》 CAS 北大核心 2013年第15期1840-1841,共2页 Jiangsu Medical Journal
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  • 1Follath F,Cleland JG,Just H, et al. Efficacy and safety ofintravenous levosimendan compared wirh dobutamine in severelow-output heart failure (the LIDO study) : a randomizeddouble-blind trial [J]. Lancet, 2002,360(9328) : 196-202.
  • 2Moiseyev VS. Poder P, Andrejevs N, et al. Safety and efficacyof a novel calcium sensitizer.levosimendan, in patients with leftventricular failure due to an acute myocardial infarction. Arandomized,placebo-controlled,double~blind study (RUSSLAN)[J]. Eur Heart J,2002,23(18) : 1422-1432.
  • 3Cleland JG,Ghosh J,Freemantle N,et al. Clinical trials updateand cumulative meta-analyses from the American College ofCardiology: WATCH, SCD-HeFT, DINAMIT, CASINO,INSPIRE, STRATUS-US, RIO-Lipids and cardiac resynchroni-sation therapy in heart failure [J], Eur J Heart Fail, 2004,6(4):501-508.
  • 4Dec GW. Acute decompensated heart failure: the shrinking roleof inotropic therapy[J]. J Am Coll Cardiol,2005,46(1) : 65-67.
  • 5黄震华.新型抗心力衰竭药物钙离子敏感药[J].中国新药与临床杂志,2002,21(11):683-685. 被引量:16
  • 6张耀春,王彦,王立为.左西孟旦的药理、毒理学研究综述[J].中国药物应用与监测,2005,2(1):59-61. 被引量:20

二级参考文献18

  • 1[2]Kopustinskiene DM,Pollesello P,Saris NE.Potassium-specific effects of levosimendan on heart mitochondria[J].Biochem Pharmacol, 2004,68(5):807.
  • 2[3]Rump AF,Acar D,Rosen R,et al. Functional and antiischaemic effects of the phosphodiesterase inhibitor levosimendan in isolated rabbit hearts[J].Pharmacol Toxicol, 1994,74( 4-5 ) :244.
  • 3[4]Yokoshiki H,Katsube Y,Sunagawa M,et al. Levosimendan,a novel Ca2+sensitizer,activates the glibenclamide-sensitive K+channel in rat arterial myocytes [J].Eur J Pharmacol,1997,333(2-3):249.
  • 4[5]Sundberg-S, Lilleberg-J, Nieminen-MS, et al. Hemodynamic an d neurohumoral effects of Levosimendan, a new calcium sensitizer,at rest and during exercise in healthy men [J].AmericanJournal-of-Cardiology, 1995,75(15): 1061.
  • 5[6]Antila S,Huuskonen H,Nevalainen T,et al. Site dependent bioavailability and metabolism of levosimendan in dogs[J]. Eur J Pharm Sci,1999,9(1):85.
  • 6[7]Antila S,Kivikko M,Lehtonen L,et al.Pharmacokinetics of levosimendan and its circulating metabolites in patients with heart failure after an extended continuous infusion of levosimendan[J].Br J Clin Pharmacol, 2004,57(4): 412.
  • 7[8]Poder P,Eha J,Sundberg S,et al. Pharmacodynamics and pharmacokinetics of oral levosimendan and its metabolites in patients with severe congestive heart failure:a dosing interval study[J].J Clin Pharmacol,2004,44( 10 ) :1143.
  • 8[9]Turanlahti M,Boldt T,Palkama T,et al.Pharmacokinetics of levosimendan in pediatric patients evaluated for cardiac surgery [J].Pediatr Crit Care Med,2004,5( 5 ):457.
  • 9[10]Figgitt DP, Gillies PS, Goa KL.Levosimendan[J].Drugs, 2001,61(5):613.
  • 10PAPP JG. Introduction: positive inotropy by calcium sensitization- an evolving approach for the treatment of end-stage heart failure[J]. Am J Cardiol, 1999, 83(12B):1-3.

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