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水通道蛋白-4的研究进展 被引量：10

Advances of Aquaporin-4 Research
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摘要 水通道蛋白-4(AQP4)主要在脑组织中表达,起着调节脑内水转运的重要功能,参与脑水肿的病理生理过程。其参与星形细胞对K+摄取和释放,神经胶质细胞迁移,神经胶质瘢痕形成的生理过程。AQP4参与了许多疾病病理过程,如癫、视神经脊髓炎。AQP4可能为中枢神经系统疾病治疗提供新的途径。 Aquaporin-4（AQP4）,a major aquaporin in brain,plays an important role in regulating water transfer when brain edema occurs.It is involved in potassium uptake and release by astrocytes,migration of glial cells and glial scarring.And it is also involved in multiple disease processes in brain,such as seizures and neuromyelitis optica.So AQP4 may become a therapeutic target in central nervous system diseases.
作者 张士保 代大伟 代亚美
机构地区 哈尔滨医科大学附属第一医院神经内科
出处 《中国临床神经科学》 2013年第4期451-455,共5页 Chinese Journal of Clinical Neurosciences
基金 黑龙江省青年科学基金(编号:QC2009C77) 哈尔滨医科大学一院科研基金(编号:B018-016)
关键词 水通道蛋白-4 中枢神经系统 脑水肿 钾离子 胶质细胞 aquaporin-4 central nervous system brain edema K＋ glial cells
分类号 R742.7 [医药卫生—神经病学与精神病学]
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参考文献55

  • 1Verkman AS. More than just water channels unexpected cellularroles of aquaporins [J]. J Cell Sci,2005,118:3225-3232.
  • 2Iacovetta C, Rudloff E,Kirby R. The role of aquaporin 4 in the brain[J]. Vet Clin Pathol,2012,41:32-44.
  • 3Cui Y,Bastien DA. Water transport in human aquaporin-4:molecular dynamics (MD) simulations[J]. Biochem Biophys ResCommun,201,412:654-659.
  • 4Furman CS, Gorelick-Feldman DA, Davidson KG, et al. Aquaporin-4square array assembly: opposing actions of Ml and M23 isoforms[J]. Proc Natl Acad Sci U S A,2003,100:13609-13614.
  • 5Sorani MD, Zador Z, Hurowitz E, et al. Novel variants in humanAquaporin-4 reduce cellular water permeability [J]. Hum Mol Genet,2008,17:2379-2389.
  • 6Masato Y. Regulation,structure and function of brain aquaporin[J]. Rinsho Shink-eigaku,2009,49:786-788.
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  • 8Yang M, Gao F, Liu H, et al. Immunolocalization of aquaporin inrat brain[J]. Anat Histol Embryol,2011,40:299-306.
  • 9Tait MJ, Saadoun S, Bell BA, et al. Water movements in the brain:role of aquaporins[J].Trends Neurosci,2008,31:37-43.
  • 10Yasui M. Aquaporin from basic to clinical medicine: roles in brainedema[J]. No To Hattatsu,2011,43:191 -194.

二级参考文献20

  • 1Yang B.The human aquaporin gene family (review)[J].Current Genomics,2000, 1:9 1- 102
  • 2Rash JE, Yasumura T, Hudson CS,el at. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord[J]. Proc Natl Acad Sci USA, 1998,95:11981-11986
  • 3Lu M,Lee MD,Smith B.The human AQP4 gene:definition of the locus encoding two water channel polypeptlde[J]. Proc Natl Acad Sci USA, 1996,93:10908-10912
  • 4Verkman AS.Physiological importance of aquaporin water channels [J].Ann Med,2002,34:192-200
  • 5Verkman AS.Applications of aquaporin inhibitors[J]. Drug News Perspect,2003,14:412-420
  • 6Venero JL,Vizuete ML,Machado A,et al,Aquaporins in the central nervous system[J].Prog Neurobiol,2001, 63:121 - 130
  • 7Yamamoto N,Yoneda K,Asai K,et al.Alteration in the expression of AQP family incultured rat astrocytes hypoxia and reoxygenation [J].Brain Res Mol Brain Res,2001,90:21-24
  • 8Saadoun S, Papadopoulos MC,Davies DC,et al.Aquaporin-4 expression is increased in oedematous human brain tumors[J].J Neurol Neurosurg Psychiatry,2002,72:262-265
  • 9Amiry-Moghaddam M,Xue R,Hang FM,et al.Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia[J]. J FASEB,2004,18:542-544
  • 10Oshio K, Binder DK, Yang B, et al.Expression of aquaporin water channels in mouse spinal cord[J]. Neuroscience,2004,127:685-693

共引文献1

同被引文献143

引证文献10

二级引证文献41

中国临床神经科学
2013年 第4期

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