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奥曲肽联合谷氨酰胺治疗重症急性胰腺炎90例 被引量:3

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摘要 目的探讨奥曲肽联合谷氨酰胺治疗重症急性胰腺炎患者的临床疗效。方法重症急性胰腺炎患者182例,随机分为对照组92例和治疗组90例。对照组给予胃肠减压、禁食、部分可以行胰管减压术(鼻胆管引流),补充有效血容量,清蛋白,预防性应用抗菌药物,维持电解质及酸碱平衡,营养支持。奥曲肽注射液100μg加入10%葡萄糖注射液中静脉滴注,25μg.h-1,疗程3~7 d。治疗组在对照组治疗基础上,联合应用谷氨酰胺100μg,加入0.9%氯化钠注射液5倍稀释,静脉滴注,100 mL.d-1,疗程3~7 d。观察两组血清淀粉酶(AMS)、白细胞(WBC)、血糖(Glu)、三酰甘油(TG)、总胆固醇(TC)、血清C-反应蛋白(CRP)的变化。结果对照组总有效率77.2%,治疗组总有效率90.0%,差异有统计学意义(P<0.05)。治疗组血清淀粉酶、白细胞、血糖、TG、TC、血清CRP恢复正常的时间优于对照组,差异有统计学意义(P<0.05)。结论奥曲肽联合谷氨酰胺治疗重症急性胰腺炎患者疗效好且安全,临床可进一步推广。
作者 林方德
出处 《医药导报》 CAS 北大核心 2013年第7期892-893,共2页 Herald of Medicine
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  • 1马良忠.奥曲肽治疗急性胰腺炎疗效观察[J].中国实用内科杂志,2013,33(S2):32-33. 被引量:5
  • 2Mukaddes E■refoglu,Mehmet Gül,Burhan Ate■,Kadir Batoglu,Mukadder Ay■e Selimoglu.Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats[J].World Journal of Gastroenterology,2006,12(2):259-264. 被引量:31
  • 3LAUKKARINEN J M,VAN ACKER G J,WEISS E R,et al. A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate [ J ]. Gut, 2007,56 : 1590-1598.
  • 4BROWN E M,SADARANGANI M,FINLAY B B. The role of the immune system in governing host-microbe interactions in the intestine [ J]. Nat Immunol,2013,14(7) :660-667.
  • 5ZAMOLODCHIKOVA T S. Serine proteases in immune pro- tection of the small intestine [ J ]. Biochemistry ( Mosc ), 2013,78(3) :213-220.
  • 6RAKHSHANDEH A, DEKKERS J C, KERR B J, et al. Effect of immune system stimulation and divergent selection for residual feed intake on digestive capacity of the small intestine in growing pigs [ J ]. J Anim Sci, 2012,90 ( Suppl 4) :233-235.
  • 7LIMA P R, DE MELO T S, CARVALHO K M, et al. 1,8- cineole (eucalyptol)ameliorates cerulein-induced acute pancreatitis via modulation of eytokines, oxidative stress and NF-KB activity in mice [ J ]. Life Sei, 2013,92 ( 24-26 ) : 1195-1201.
  • 8PUPELIS G, PLAUDIS H, ZEIZA K, et al. Early continuous veno-venous haemofihration in the management of severe acute panereatitis eomplieated with intra-abdominal hypertension: retrospective review of 10 years" experience [ J ]. Ann Intensive Care, 2012,2 ( Suppl 1 ) : S1.
  • 9ZHANG H, NEUHOFER P, SONG L, et al. IL-6 trans- signaling promotes panereatitis-assoeiated lung injury and lethality [ J ]. J Clin Invest,2013,123 ( 3 ) : 1019-1031.
  • 10RAMACHANDRAN R, MORICE A H, COMPTON S J. Proteinase-activated receptor-2 agonists upregulate granulocyte colony-stimulating factor, IL-8, and VCAM-1 expression in human bronchial fibroblasts[ J]. Am J Respir Cell Mol Bio1,2006,35 ( 1 ) : 133-141.

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