维格列汀有效控制空腹血糖和减少血糖波动:从基础到临床
Dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting plasma glucose with lower glycemic excursion:basic science to the clinic
摘要
空腹血糖和血糖波动不仅描述血糖变化状况,也是影响2型糖尿病患者预后的重要指标。空腹血糖和血糖波动的改善将有效降低2型糖尿病发生微血管和大血管并发症的风险。新型口服降糖药维格列汀,因具有快速持久提供体内活性GLP-1水平和双向调节胰岛细胞分泌功能的独特机制,使其能够更好地控制空腹血糖和血糖波动。
出处
《药品评价》
CAS
2013年第13期42-44,共3页
Drug Evaluation
参考文献14
-
1Levitzky YS, Pencina MJ, D'Agostino RB, et al. Impact of impaired fastingglucose on cardiovascular disease: the Framingham Heart Study. J Am CollCardiol. 2008;51(3):264-70.
-
2Boden-Albala B, Cammack S,Chong J, et al. Diabetes, fasting glucose levels,and risk of ischemic stroke and vascular events: findings from the NorthernManhattan Study (NOMAS). Diabetes Care. 2008;31(6): 1132-7.
-
3Kilpatrick ES, Rigby AS, Atkin SL. A1C variability and the risk ofmicrovascular complications in type 1 diabetes: data from the Diabetes Controland Complications Trial. Diabetes Care. 2008;31(11 ):2198-202.
-
4Barbieri M, Rizzo MR, Marfella R, et al. Decreased carotid atheroscleroticprocess by control of daily acute glucose fluctuations in diabetic patients treatedby DPP-IV inhibitors. Atherosclerosis. 2013;227(2):349-54.
-
5Hermanides J, Vriesendorp TM, Bosman RJ, et al. Glucose variability isassociated wifli intensive care unit mortality.
-
6张儒雅,陆菊明.DPP-4抑制剂在2型糖尿病治疗中的应用[J].中华内分泌代谢杂志,2011,27(1):101-104. 被引量:75
-
7Ahren B, Schweizer A, Dejager S, et al. Mechanisms of action of thedipeptidyl peptidase-4 inhibitor vildagliptin in humans. Diabetes Obes Metab.2011;13(9):775-83.
-
8Davis JA, Singh S, Sethi S, et al. Nature of action of Sitagliptin, the dipeptidylpeptidase-IV inhibitor in diabetic animals. Indian J Pharmacol. 2010;42(4):229-33.
-
9Marfella R, Barbieri M, Grella R, et al. Effects of vildagliptin twice dailyvs. sitagliptin once daily on 24-hour acute glucose fluctuations. J DiabetesComplications.2009;24:79-83.
-
10He YL. Clinical pharmacokinetics and pharmacodynamics of vildagliptin. ClinPharmacokinet. 2012;51 ⑶:147-62.
二级参考文献30
-
1Goke B.Islet cell function:alpha and beta cells-partners towards normoglycaemia.Int J Clin Pract Suppl,2008,(159):2-7.
-
2Kim MH,Lee MK.The incretins and pancreatic beta-cells:use of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide to cure type 2 diabetes Mellitus.Korean Diabetes J,2010,34:2-9.
-
3Kim W,Egan JM.The role of incretins in glucose homeostasis and diabetes treatment.Pharmacol Rev,2008,60:470-512.
-
4Neumiller JJ,Wood L,Campbell RK.Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.Pharmacotherapy,2010,30:463-484.
-
5Deacon CF.Circulation and degradation of GIP and GLP-1.Horm Metab Res,2004,36:761-765.
-
6Deacon CF,Carr RD,Holst JJ.DPP-4 inhibitor therapy:new directions in the treatment of type 2 diabetes.Front Biosci,2008,13:1780-1794.
-
7Lankas GR,Leiting B,Roy RS,et al.Dipeptidyl peptidase Ⅳ inhibition for the treatment of type 2 diabetes:potential importance of selectivity over dipeptidyl peptidases 8 and 9.Diabetes,2005,54:2988 -2994.
-
8Holst JJ,Deacon CF.Inhibition of the activity of dipeptidyl-peptidase Ⅳ as a treatment for type 2 diabetes.Diabetes,1998,47:1663-1670.
-
9Ahren B,Holst JJ,Martensson H,et al.Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase Ⅳ in mice.Eur J Pharmacol,2000,404:239-245.
-
10Mari A,Sallas WM,He YL,et al.Vildagliptin,a dipeptidyl peptidase-Ⅳ inhibitor,improves model-assessed beta-cell function in patients with type 2 diabetes.J Clin Endocrinol Metab,2005,90:4888-4894.
共引文献74
-
1殷雪燕,焦雪花,沈晓华,李赓煦.西格列汀治疗2型糖尿病非增殖性视网膜病变的临床观察[J].智慧健康,2021,7(31):102-104.
-
2刘敏超,杨羚,呼永河,谢春光,罗巧.浅议胆玄府理论及开玄法在糖尿病中的运用[J].四川中医,2022,40(11):16-19.
-
3王甫能,魏爱生,陈苹,李阳,麦伟华,劳美铃.联合维格列汀治疗对阿卡波糖控制不佳的新诊断2型糖尿病患者血糖波动的影响[J].广东医学,2019,40(S01):117-119. 被引量:5
-
4吴德云,马维青,汪沪光,吕芳,王国娟,胡国平,司玮.2型糖尿病患者单用二甲双胍血糖控制不佳加用二肽基肽酶-4抑制剂西格列汀疗效观察[J].临床荟萃,2011,26(20):1762-1764. 被引量:15
-
5陆菊明.2型糖尿病治疗新药沙格列汀的药理及临床评价[J].中国新药杂志,2011,20(21):2039-2043. 被引量:40
-
6朱大龙,李平.DPP-4抑制剂的作用机制及在2型糖尿病治疗中的应用[J].中华内分泌代谢杂志,2011,27(11). 被引量:13
-
7郑瑕南,李红.维格列汀和二甲双胍联合治疗2型糖尿病的疗效与安全性[J].中华内分泌代谢杂志,2011,27(12). 被引量:17
-
8陆菊明.沙格列汀的临床研究进展[J].中国糖尿病杂志,2012,20(4):316-320. 被引量:39
-
9曹月香.甘精胰岛素和中效胰岛素治疗2型糖尿病疗效比较[J].山东医药,2012,52(22):60-61. 被引量:4
-
10石卫峰,李晓宇,刘皋林.治疗2型糖尿病新药利拉利汀[J].中国新药杂志,2012,21(20):2346-2348. 被引量:2
-
1杨洁怡.甲状腺功能亢进症患者糖耐量异常分析[J].中国现代医生,2010,48(36):149-150. 被引量:7
-
2甘喜.西格列汀联合二甲双胍治疗初诊2型糖尿病的疗效观察[J].临床医学工程,2014,21(12):1577-1578. 被引量:5
-
3王新宜.甲亢患者糖耐量的改变及胰岛素抵抗的研究[J].中国当代医药,2010,17(22):28-29. 被引量:5
-
4王东,陈军建,袁国跃,杨玲,陈霞,王济芳.诺和锐30与诺和灵30R治疗老年2型糖尿病的有效性和安全性[J].中国老年学杂志,2012,32(16):3522-3523. 被引量:8
-
5尹妍.依那普利联合倍他乐克对高血压患者的疗效分析[J].吉林医学,2015,36(4):709-710. 被引量:2
-
6张硕人,李丽萍.地特胰岛素联合门冬胰岛素皮下注射治疗69例T2DM的疗效分析[J].临床医药文献电子杂志,2017,4(1):165-166. 被引量:1
-
7施国丽.无症状心肌缺血应用参脉注射液配合丹红注射液治疗的临床探讨[J].中外医疗,2014,33(30):46-47. 被引量:1
-
8肖杰平.比索洛尔对COPD合并慢性心衰患者心肺功能的影响分析[J].当代医学,2015,21(29):128-129. 被引量:4
-
9Rajan E,Clain J.E,Levy M.J,陈云茹.超声内镜确定胰腺随年龄增长的变化状况:一项前瞻性研究[J].世界核心医学期刊文摘(胃肠病学分册),2005,0(8):33-33. 被引量:2
-
10周铀.冠心病患者应用曲美他嗪与阿托伐他汀联合治疗的临床分析[J].心血管病防治知识(学术版),2015,5(2):61-62. 被引量:1