摘要
以三氟甲基苯、固体甲醛和氯磺酸作原料,在硫酸催化剂的作用下,进行氯甲基化反应,生成间三氟甲基氯苄。然后,在季胺盐(如四丁基溴化铵)相转移催化剂的作用下,用间三氟甲基氯苄与氰化钠水溶液进行氰化反应,制得三氟甲基苯乙腈粗品,经分水、减压蒸馏提纯,得到低含水量(m-TAN含量>94%,水分≤2×10-4)的间三氟甲基苯乙腈产品。
With trifluoromethyl benzene, paraformaldehyde and chlorosulfonic acid as raw materials, prepared m-trifluo- romethyl benzyl chloride through chloromethylation in the presence of sulfuric acid. Then, synthesized m-trifluoromethyl phenylacetonitrile （TAN） crude products by the reaction of m-trifluoromethyl benzyl chlolide and sodium cyanide in the pres- ence of quaternary ammonium phase transfer catalyst, such as tetrabutyl ammonium bromide. After dehydration and vacuum distillation, obtained low water m-trifluoromethyl phenylaeetonitrile （m-TAN〉94%, H2O≤2×10-4）.
出处
《上海化工》
CAS
2013年第8期13-16,共4页
Shanghai Chemical Industry
关键词
三氟甲基苯
氯甲基化反应
季胺盐
氰化钠
间三氟甲基苯乙腈
Trifluoromethyl benzene
Chloromethylation
Quaternary ammonium
Sodium cyanide
m-Trifluoromethyl phenylacetonitrile
