摘要
介绍近年国外地喹氯铵类似物构效关系的研究状况。方法 :根据对有关资料的分析 ,归纳总结了地喹氯铵、钾离子通道的药理作用 ,地喹氯铵类似物的构效关系等。结果 :地喹氯铵类似物的结构与小电导钙离子激活的钾离子通道 (SKCa)存在定量构效关系。结论 :地喹氯铵类似物的构效关系的研究对寻找最适宜的人工合成SKCa阻滞剂有重要意义。
Objective:To introduce the advances of study on structure-activity relationships of dequalinium analogues. Methods:The relevant data were further analyzed and concluded. Results:It was showed that dequalinium chloride was the most potent nonpeptidic blocker of the SK Ca channel so far described. Conclusion:There is an important meaning that study on the structure-activity relationship of dequalinium chloride analogues for searching the most appropriate synthetic SK Ca channel blockers.
出处
《医药导报》
CAS
2000年第3期267-268,共2页
Herald of Medicine
关键词
地喹氯铵
构效关系
阻滞活性
钾离子通道
Dequalinium chloride Structure-activity relationship Blocking activity SK_(Ca)
