摘要
目的 :观察慢性肺心病患者急性发作期和缓解期血清肿瘤坏死因子 - α(TNF- α)浓度 ,旨在探讨 TNF- α在肺心病发病中的作用。方法 :采用放射免疫分析法测定 30例患者血清肿瘤坏死因子 - α,试剂盒由解放军总医院提供并检测。同步检测血象、血肌酐、动脉血氧分压 (Pa O2 )、动脉血二氧化碳分压(Pa CO2 ) ,观察症状、体征变化 ,并与 2 1例健康者进行比较。结果 :肺心病发作期和缓解期血清 TNF- α水平均较正常对照组增高 ,尤其在发作期增高明显 ,差异有显著性 (P<0 .0 1) ,并与临床症状、体征、血气、血象及血生化呈动态改变。结论 :TNF- α可能在肺心病中起着重要的作用。测定血清 TNF- α的变化对肺心病病程的分析 ,指导临床治疗等具有一定的意义。
Objective:To examine the levels of tumor necrosis factor(TNF\|α) in patients with chronic cardiac puimonale(CCP)and to determine the relationship between TNF-α and CCP.Methods:The serum levels of TNF\|α in patients with CCP and healthy controls were measured by radioimmunoassay.Results:showed that serum levels of TNF\|α in patients with CCP during exacerbation and stable stage were higher than that in the controls( P <0 01),especially in the former( P <0 001).Conclusions:Serum TNF\|α increased markedly in severe infectious cases and decreased in release stase accompanied with chinical and PaCO 2、PaO 2.Conclusions These findings suggest that TNF-α may be an useful referential indicator for diagnosing monitoring and predicting CCP. [
出处
《中国民政医学杂志》
2000年第5期282-283,共2页
Medical Journal of Chinese Civil Administration
关键词
肺心病
肿瘤坏死因子
机理
检测
Chronic cardiac puimonale
Tumor necrosis factor
