摘要
目的 :探讨吸入呋塞米对支气管哮喘 (哮喘 )病人气道反应性的影响。方法 :缓解期哮喘病人4 0例 ,随机分为A ,B 2组 ,每组各 2 0例。试验分 2次隔日交叉吸入 0 .9%氯化钠注射液 4mL或呋塞米 4 0mg后予组胺吸入激发试验。结果 :2组病人吸入 0 .9%氯化钠注射液后的组胺PC2 0 FEV1差异无显著意义 (P >0 .0 5) ;吸入呋塞米后的组胺PC2 0 FEV1差异亦无显著意义 (P >0 .0 5) ;但 2组病人吸入呋塞米后的组胺PC2 0 FEV1均显著高于其吸入0 .9%氯化钠注射液后的组胺PC2 0 FEV1(均P <0 .0 5)。结论 :吸入呋塞米可抑制哮喘病人的气道高反应性。
AIM: To investigate the effect of inhaled furosemide on bronchial responsiveness in patients with asthma. METHODS: Forty patients with stable asthma were randomly divided into A and B group. The patients of group A ( n =20) inhaled 4 mL saline and group B ( n =20) inhaled 40 mg furosemide in d 1, the patients of group A inhaled 40 mg furosemide and group B inhaled 4 mL saline in d 3. All patients were given histamine provocation test after inhalation of saline or furosemide. RESULTS: No significant difference was observed in mean PC 20-FEV1 between group A and group B after inhalation of saline or after inhalation of furosemide, while the mean PC 20-FEV1 after inhalation of furosemide was significantly higher than the mean PC 20-FEV1 after inhalation of saline in group A and group B. CONCLUSION: Furosemide given by inhalation can inhibit bronchial responsiveness in patients with asthma.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2000年第6期475-476,共2页
Chinese Journal of New Drugs and Clinical Remedies
