摘要
1目的 探讨福辛普利对血压正常的 2型糖尿病病人胰岛素敏感性的干预作用。 2方法 观察 6 2例血压正常的 2型糖尿病病人治疗前后胰岛素敏感性的变化 ,其中 31例服用福辛普利 (治疗组 ) ,31例未服用福辛普利 (对照组 ) ,治疗时间 90 d.3结果 治疗组治疗后空腹血糖、血清胰岛素、葡萄糖曲线下面积和胰岛素曲线下面积较治疗前及对照组均降低 ,胰岛素敏感性指数升高 ,差异均有显著意义 (t=3.372～ 13.5 98,P<0 .0 1) ;胰岛素曲线下面积 /葡萄糖曲线下面积 (I/ G)比值无明显变化。对照组仅见空腹血糖和葡萄糖曲线下面积降低 (t=2 .86 3,8.75 4,P<0 .0 1) ,而 I/ G比值增加 (t=2 .5 71,P<0 .0 5 )。 4结论 福辛普利可增强 2型糖尿病病人的胰岛素敏感性 。
Objective\ To study the interventional effect of frosinopril on the insulin sensitivity in patients with type 2 diabetes with normal blood pressure.\ Methods\ Insulin sensitivity of 62 type 2 diabetic patients with normal blood pressure was investigated before and after the study, 31 of them took frosinopril (therapeutic group), and the other 31 as control group.\ Results At the end of study, both FSG,FINS,GAUC and IAUC of therapeutic group decreased, while IS increased and there was no changes in I/G ratio. For the control group, only the FSG and GAUC decreased with an increase of I/G ratio.\ Conclusion Frosinopril can enhance the insulin sensitivity of patients with type 2 diabetes mellitus and decrease insulin resistance. [
出处
《齐鲁医学杂志》
2000年第4期253-254,共2页
Medical Journal of Qilu
关键词
福辛普利
Ⅱ型糖尿病
胰岛素敏感性
干预性
frosinopril
diabetes mellitus, non insulin dependent
insulin sensitivity
intervention studies
