摘要
目的 探讨糖尿病性血管病变与血浆低密度脂蛋白 (OX- L DL )及可溶性细胞间黏附分子 - 1(s ICAM- 1)水平变化的关系。 2方法 采用酶联免疫吸附法 (EL ISA) ,检测了 6 0例 2型糖尿病 (NIDDM)病人和48例健康人血浆 OX- L DL和 s ICAM- 1水平变化。 3结果 NIDDM病人血浆 OX- L DL ,s ICAM- 1水平明显增高 ,与对照组比较差异有极显著性 (t=13.0 0 0 ,2 1.2 94,P<0 .0 0 1) ;且有血管病变者 OX- L DL ,s ICAM- 1水平明显高于无血管病变者 (t=7.0 2 1,11.2 0 3,P<0 .0 0 1)。 NIDDM病人血浆 OX- L DL与 s ICAM- 1呈正相关 (r=0 .774,P<0 .0 0 1)。 4结论 糖尿病性血管病变的发生与血浆 OX- L DL ,s ICAM-
Objective To explore the relationship between the diabetic angiopathy and the plasma oxidized low density lipoprotein(OX LDL) and soluble intercellular adhesion molecule 1(sICAM 1).\ Methods\ The changes of OX LDL,sICAM 1 level were measured in 60 patients with type 2 diabetes mellitus(NIDDM) and 48 healthy subjects by ELISA technic.\ Results The OX LDL, sICAM 1 levels were significantly higher in NIDDM patients than those in the controls( t=13.000,21.294, P < 0.001 ), and the increase of OX LDL, sICAM 1 was more obvious in patients with angiopathy than those without angiopathy( t= 7.021 , 11.203, P <0.001). In NIDDM patients, the OX LDL was positively correlated with sICAM 1( r=0.774, P < 0.001 ). Conclusion \ Diabetic angiopathy was closely related to the increase of OX LDL and sICAM 1 levels.
出处
《齐鲁医学杂志》
2000年第2期79-80,共2页
Medical Journal of Qilu
