摘要
目的 制备稳定的树脂微囊混悬剂。方法 考察常用亲水性聚合物甲基纤维素 (MC) ,羟丙基甲基纤维素 (HPMC) ,聚维酮K90 (PVPK90 ) ,卡波姆 (Carbopol) ,微晶纤维素 (Avicel)及黄原胶等辅料对树脂微囊的助悬效果。通过对其沉降体积比、絮凝度及再分散性的考察 ,筛选有良好助悬行为的Carbopol,Avicel作为处方中的助悬剂 ,从流变学、空白介质与混悬剂粘度的差异、显微观察、聚电解质影响等方面对其稳定机制进行探讨。结果与结论 实验表明 ,仅仅提高体系的粘度无法使微囊稳定悬浮 ;Avicel是由于不溶性的MCC微粒吸附CMC后在水中形成空间固体筛 ,支撑树脂微囊 ,从而起到助悬效果 ;而Carbopol是通过其分子与树脂微囊间单点或多点吸附产生空间架桥 。
S:OBJECTIVE To prepare physically stable resin-microcapsule suspension.METHODS To investigate the suspending effect of following hydrophilic polymer: MC,HPMC,PVPK90,Carbopol, Avicel and Xanthan gum. Carbopol and Avicel appeared to bea satisfying suspending agent by evaluating the sedimentation rate, flocculation and its redispersion. The mechanism was studied by detecting the rheology property,the difference between suspending medium and suspension, microscopic analysis and the influence of polyelectrolyte.respectively.RESULTS and CONCLUSION The microcapsule failed to be stablysuspended by increasing the viscosity of medium alone. Avicel supported resinmicrocapsule by the threedimension structurevehicle which was formed through the adsorption of MCC on microcapsule. Carbopol stabilized resin-microcapsule by 'bridging effect' through its single or multipoint adsorption on microcapsule.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2000年第8期527-530,共4页
Chinese Pharmaceutical Journal
基金
国家"九五"攻关资助项目!(96-902-02-05)
