摘要
目的 :通过对国内 3个厂家生产的特非那丁片溶出度测定 ,考察其质量。方法 :转篮法 ,用高效液相色谱法检测 ,提取参数 (T50 、Td、m) ,并对参数进行相关性检验。结果 :不同厂家产品溶出参数差异显著。结论 :对国内厂家的特非那丁片有必要增加溶出度考察 ,以控制其质量。
OBJECTIVE:To compare the dissolution rates of domestically-made terfenadine tablets.METHODS:According to Chinese Pharmacopoeia(1995) dissolution method Ⅱand HPLC,the parameters( T 50 , T d, m ) obtained from these samples were brought for correlation analysis.RESULTS:The dissolution rate of terfenadine tablets from various domestic factories were remarkably different.CONCLUSIONS:The method of determination for terfenadine tablets is acceptable.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2000年第8期471-473,共3页
Chinese Journal of Hospital Pharmacy
