摘要
目的 :对克林沙星的抗菌活性进行研究。方法 :克林沙星的最小抑菌浓度 (MIC)检测采用试管肉汤稀释法 ,其半数有效量 (ED50 )的检测通过对感染小鼠的试验性治疗来实现。结果 :克林沙星对嗜麦芽窄食单胞菌以外的全部实验菌的MIC90 为0 .0 3～ 2 .0mg·L-1,低于单次口服克林沙星 2 0 0mg在血浆中的峰浓度 (2 .5mg·L-1) ;克林沙星的MIC值为环丙沙星的 1/ 8～ 1/ 2 ,ED50 为环丙沙星的 1/ 3～ 1。结论 :克林沙星体内体外的抗菌活性较环丙沙星为优 ,是一个广谱高效的新喹诺酮类抗菌药。
OBJECTIVE:To study the antimicrobial activity of clinafloxacin.METHODS:The minimal inhibitory concentration(MICs) of clinafloxacin were determined by broth macrodilution method and 50% effective doses(ED 50 ) of clinafloxacin were measured by experimental treatment of infected mice.RESULTS:The MIC 90 of all isolates excluding stenotrophomonas maltophilia were from 0.03 to 2.0 mg·L -1 and which were lower than the peak plasma concentration achieved after oral single dose of 200 mg. MICs of clinafloxacin were about 1/8～1/2 times that of ciprofloxacin and the ED 50 about 1/3～1 times.CONCLUSIONS:The in vivo and in vitro activity of clinafloxacin is higher than ciprofloxacin.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2000年第8期463-465,共3页
Chinese Journal of Hospital Pharmacy
关键词
克林沙星
最小抑菌浓度
半数有效量
clinafloxacin
ciprofloxacin
minimal inhibitory concentration
ED 50
