摘要
目的探讨2型糖尿病患者血浆同型半胱氨酸（Hcy）与颈动脉内膜中层厚度（IMT）的相关性。方法根据颈动脉IMT将54例2型糖尿病患者分为IMT正常组和IMT增厚组，并选择30例健康人作为对照组，分别进行血浆Hcy的测定并比较。结果糖尿病组Hcy水平为（24．77±10，17）μmol／L，高于健康对照组的（10．95±2．60）p．mol／L（P〈0．05）。IMT增厚组Hcy水平为（19．80±4．97）μmol／L，显著高于非IMT增厚组的（15．00±4．83）μmol／L（P〈0．05）。糖尿病患者血浆Hcy与颈动脉IMT增厚呈正相关（r=0，6384，P〈0．05）。结论高Hcy是2型糖尿病患者动脉粥样硬化的独立危险因素。
Objective To investigate the correlation between the plasm level of homocysteine （Hcy）and ca- rotid intimal-medial thickness（IMT） in type 2 diabetes（T2DM）. Methods 54 patients with preliminary diagnosis of T2DM were divided into two groups according to IMT level： normal IMT group and IMT increased group, 30 healthy people were chosen as control. Hcy were detected in all patients and healthy people, Results Hcy levels in T2DM was （24.77±10. 17 ） μmol/L, which was higher than that in healthy people [ （ 10.95 ±2.60）μmol/L ] （ P 〈 0.05 ）. Hcy levels in IMT increased group was （ 19.80 ± 4. 97） μmol/L, which was higher than that in normal IMT group [ （15.00±4.83）μmol/L] （P 〈0.05）. The positive correlation between Hcy and IMT in T2DM was shown（r =0.6384,P 〈 0.05）. Conclusion High Hcy was an independent risk faotor of atherosclerosis in patients with type 2 diabetes.
出处
《中国基层医药》
CAS
2013年第18期2800-2801,共2页
Chinese Journal of Primary Medicine and Pharmacy
