摘要
目的研究不稳定性心绞痛（ＵＡ）患者内皮细胞的损伤和功能变化。方法５４例ＵＡ患者为实验组，５４例健康人作为对照组。以循环内皮细胞（ＣＥＣ）作为血管内皮损伤的指示物，血浆内皮素（ＥＴ－１）反映血管内皮的功能变化，动态测定患者在入院后４８ｈ内的血浆ＥＴ－１水平，ＣＥＣ计数，对照组同时测定。结果实验组血浆ＥＴ－１和ＣＥＣ均在ＵＡ早期４ｈ就达峰值，明显高于正常对照组（Ｐ＜０．０１）。随后逐渐下降，４８ｈ后各测定值接近正常对照组，实验组的ＥＴ－１和ＣＥＣ呈显著正相关（Ｐ＜０．００１）。结论血浆ＥＴ－１和ＣＥＣ水平在ＵＡ早期显著增加，可作为不稳定性心绞痛内皮细胞损伤和功能变化的指标。［
Objective To investigate the endothelial injury and dysfunction in patients with unstable angina (UA). Methods Fifty-four UA patients were test group, and 54 normal person were compare group. Circulat- ing endothelial cells (CEC) were used as an endothelial injury indicator and the plasma level of endothelin (ET-1) as the functional marker of the vascular endothelial cells. Plasma ET-1 levels and the number of CEC were detected dynamically in 54 UA patients within 48 hours. Results Plasma ET-1 levels and the number of CEC in test group rose sharply after the onset of chest pain and reached a peak level after 4 hours, and were higher than that in compare group(P < 0.01), Then lowed gradually which were same as compare group after 48 hours. There were significant positive correlation between ET-1 and CEC in test group(P < 0.01 ). Conclusion The rapid increase of ET-1 and CEC in the early phase of UA may be index of the endothelial injury and dysfunction in patient with unstable angina.
出处
《哈尔滨医科大学学报》
CAS
2000年第4期277-278,共2页
Journal of Harbin Medical University
