摘要
目的观察大鼠脑缺血－再灌注损伤时ＭｇＳＯ４对皮层脑电图、肢体运动功能及血Ｍｇ２＋浓度的影响。方法 用改良的大脑中动脉线栓法建立大鼠脑缺血－再灌注模型，进行皮层脑电图描记、血清Ｍｇ２＋浓度测定及运动功能 评估。结果 ＭｇＳＯ４能减少扩展性抑制波（ＳＤｓ）产生数（Ｐ＜０．０５）；１０％ ＭｇＳＯ４治疗组疗效优于５％ＭｇＳＯ４组，且早 期给药效果更佳（Ｐ＜０．０５）。结论ＭｇＳＯ４作为兴奋性氨基酸（ＥＥＡｓ）非竞争性Ｎ－甲基－Ｄ－天门冬氨酸受体（ＮＭＤＡ－ Ｒ）拮抗剂可有效减少ＳＤｓ产生数，对大鼠脑缺血－再灌注损伤有保护作用。
Objective To observe the changes of conical spreading depressions (SDs), motive function and Mg2+ concentration in serum in rats with ischemia-reperfusion treated by MgSO4 .Methods The animal model of reformed middle cerebral artery occlusion was made in 120 rats. The changes of cortical SDs and Mg2+ concentration in serum in the rats were observed. Twenty-four hours after operation, the motive function was evaluated according to 0 - 5 grades.Results The motive function in rats was obviously improved after given higher dose of MgSO4 in earlier stage; MgSO4 significantly reduced the number of SDs; 10% MgSO4 has better neuroprotective effect than 5% MgSO4 and the much better effect was found in the MgSO4 group given in earlier stage. Conclusion MgSO4 as a non-competitive of NMDA-R can reduce the number of SDs significantly and exhibit protective effect during cerebral ischemia-reperfusion injury.
出处
《哈尔滨医科大学学报》
CAS
2000年第4期258-260,共3页
Journal of Harbin Medical University
关键词
脑缺血
再灌注损伤
MgSO4
大鼠
电生理
cerebral ischemia-reperfusion injury
MgSO4
spreading depressions
cerebral protection
rat
