摘要
目的 用声学定量技术 ,建立诊断移植肾微结构和微循环改变的方法。 方法 应用背向散射积分、超声造影对比、二次谐波和常规多普勒超声技术 ,对术后 10d内 2 7例共 30人次移植肾脏进行检测。 结果 5例移植术失败者 ,灌注清除曲线与基线平行 ,声学定量值低。其余病例造影剂灌注区的灌注 清除曲线均呈山峰状 ,峰值密度 (PI)、灌注 清除曲线下面积 (AUC)和降支减半时间 (HT)造影后均较造影前显著增高 (P <0 0 5 ) ,视觉判断差异明显 ;移植肾脏出现排斥反应区血流灌注不良、声学定量值低 ,造影后表现为充盈缺损区 ,与正常区和正常移植肾比较定量分析差异均有显著意义 (P <0 0 5 )。 结论 异体移植肾脏排斥反应区灌注不良 ,声学密度定量值低。声学密度较常规超声 ,在诊断组织信号密度较小改变时更加敏感。新型超声诊断技术是相对无创、诊断准确而可靠的检测肾脏移植术成败的先进手段。
Objective[WT5”BZ] To establish a new method for observing renal allografts microcirculation and microstructure with acoustic densitometry (integrated backscatter, contrast, second harmonics). [WT5”HZ]Methods[WT5”BZ] 27 patients with renal allografts were investgated by Doppler,IBS, contrast and second harmonics. Renal allografts failed age in 5 patients 20 61 years. Intravenous injection of SHU 508A was given, compared with pre injection by quantitative assessment of acoustic densitometry (AD)of renal microstructure. [WT5”HZ]Results[WT5”BZ] There was a significant difference in the peak intensity,the area under the curve and the half time of wash out between pre injection and injection contrast agent. The wish in and wish out curve was shown in a peak shape. The renal allografts with acute rejection were significantly lower than the control group in AD ( P <0.05).No contrast opacification of renal microstructure was present in 5 failed renal allografts and the wish in and wish out curve appeared in a straight line shape. [WT5”HZ]Conclusion[WT5”BZ] AD is safe, and efficient in assessing renal allografts microstructure. It more sensitive in detecting allograft complication such as rejection than Doppler. [WT5”HZ]
出处
《中华外科杂志》
CAS
CSCD
北大核心
2000年第8期589-591,共3页
Chinese Journal of Surgery
关键词
超声波检查
肾移植
微循环
微结构
Ultrasonography
Kidney transplantation
Microcirculation
