摘要
从2-叔丁基- 4,5-二氯哒嗪酮出发,以两种方法合成了中间体2-叔丁基-4-氯-5-(4-溴甲基苯氧)哒嗪酮(3)。3与肟反应合成了含哒嗪酮的苄基肟醚类化合物4a～4l。在相转移催化条件下,3与芳香醛肟反应得到单一的产物4,与芳香酮肟反应则生成4和5的混合物。文中讨论了反应物的空间效应、亲核试剂对该反应区域选择性的影响,并论证了产物的构型。
An important intermidiate 2 - butyl - 4 - chloro - 5 - (4 - bromomethyl phenoxy) pyridazinone 3 was first obtained from 4,5- dichloropyridazinone using two different methods. Compounds 4a- 41 were synthesized by the reaction of 3 with different oximes. The reaction of 3 with aryl aldehyde oximes afforded exclusively the product 4 under the PTC conditions. However, led to a mixture of 4 and 5 the reaction with aryl ketone oximes. Regioselectivity of the reaction and configuration of the products are discussed.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2000年第5期758-763,共6页
Chinese Journal of Organic Chemistry
