摘要
目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是否是引起儿童肝损伤的又一独立危险因素。方法:207例患儿分为OSAHS组(130例)和对照组(77例),均行PSG、BMI、肝功能、血脂、空腹血糖和空腹胰岛素检查。结果:OSAHS组转氨酶升高者17例,对照组2例,2组比较差异有统计学意义(χ2=5.18,OR=5.64,CI 1.27-24.97);肥胖组转氨酶升高者15例,非肥胖组4例,2组比较差异有统计学意义(χ2=4.58;OR=1.97,CI 1.06-3.67);转氨酶升高的脂肪肝组中同时患OSAHS者14例(93.3%),而转氨酶正常的非脂肪肝组中患OSAHS者37例(67.3%)。结论:OSAHS为独立于肥胖之外的又一引起肝损伤的危险因素。肥胖儿童,尤其是伴有OSAHS的肥胖儿童转氨酶升高更为明显。
Objective：Obstructive sleep apnea hypopnea syndrome （OSAHS） and non-alcoholic fatty liver disease（NAFLD） are both strongly associated with obesity. Whether OSAHS is an independent risk factor for liver injury or not is uncertain. To assess the hypothesis that OSAHS is associated with liver injury independent of obesity. Method：One hundred and thirty children with OSAHS and 77 children with primary snoring（PS） were enrolled. Polysomnography was performed. Body mass index（BMI）, liver function tests, serum lipids, fasting plasma glucose（FPG） ,and insulin（INS）were measured. Result： Seventeen children of OSAHS had elevated serum aminotransferase levels,while only 2 children of non-OSAHS had elevated serum aminotransferase in healthy control group（χ^2=5.18,OR=5.64,CI 1.27-24.97）. Fifteen children of obese had elevated serum aminotransferase levels, while only 4 children had elevated serum arninotransferase in non-obese group（χ^2=4.58;OR=1.97,CI 1.06-3.67）. Seventy cases of obese children, 15 cases of elevated aminotransferase levels（21.4%）, namely fatty liver patients,of these children, 14 had OSAHS（98.3%）. In contrast, OSAHS was present in only 67.3% of obese children without elevated aminotransferase. Conclusion： OSAHS may be a risk factor for liver injury independent of obesity; Increased liver enzyme levels are frequently found in obese snoring children, particularly among those with OSAHS.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2013年第15期809-812,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
2011年济宁医学院青年基金项目(No:JYQ2011KM050)
