摘要
目的阿莫西林干混悬剂的最佳处方筛选及稳定性考察。方法应用正交试验设计,以沉降体积比和再分散性实验结果为指标,选择最佳处方配比;通过观察流变学、混悬剂黏度、显微形态以及影响因素试验和加速试验研究其稳定性。结果该处方设计合理,各项质量指标合格。结论该处方所制备的干混悬剂可达到《中国药典》相关要求。
OBJECTIVE To study the best formulation and the stability of Amoxicillin For Suspen- sion. METHODS Orthogonal design was used. The optimum formulation was investigated with the sedimentation and redispersibility as the content index. The stability of the preparation was studied by observing the rheology, sus- pension viscosity, microscopic morphology, affecting factors test and accelerated test. RESULTS The formulation is reasonable, and good stability, with all indexes up to the quality specification for suspension. CONCLUSION Thesuspension prepared according to this formula was able to meet the requirements of Chinese Pharmacopoeia on dry suspension.
出处
《海峡药学》
2013年第7期28-31,共4页
Strait Pharmaceutical Journal
关键词
阿莫西林
干混悬剂
助悬剂
稳定性
amoxicillln
suspension
suspending agent
stability
