摘要
目的研究肿瘤特异性生长因子(TSGF)和甲状腺球蛋白(Tg)联合检测诊断甲状腺癌的临床应用价值。方法 74例经病理证实的甲状腺癌患者(甲状腺癌组)和69例志愿者(正常组),使用德国IBL International公司的试剂盒检验肿瘤特异性生长因子和甲状腺球蛋白。采用统计学方法对两组的实验结果进行分析。结果正常组和甲状腺癌组之间的比较具有可行性且指标检验的准确度和精密度较高。TSGF和Tg在正常组和甲状腺癌组间的差异具有统计学意义(P<0.05),后者的水平均较高。TSGF、Tg与甲状腺癌组相关性明显(P<0.05)。TSGF、Tg以及Tg/TSGF的ROC曲线下面积均大于0.90,对甲状腺癌的诊断价值排序为:Tg/TSGF>Tg>TSGF。结论 Tg/TSGF对甲状腺癌有较高的诊断价值。
Objective -To study the clinical value of joint detection of tumor-specific growth factors （TSGF） and thyroglobulin （Tg） in the diagnosis of thyroid cancer. Methods TSGF and Tg were tested within 74 patients patho- logically confmned as thyroid cancer （the study group） and 69 volunteers （the control group）, using kits fi＇om the Ger- man IBL International. Appropriate statistical methods were used to analyze the experimental results. Results Compar- ison between the control group and the study group was feasible, with high accuracy and precision. TSGF and Tg lev- els showed statistically significant difference between the study group and the control group （P〈0.05）, which were sig- nificantly higher in the study group. TSGF and Tg levels were significantly related to thyroid cancer （P〈0.05）. Area under the curve of TSGF, Tg and Tg/TSGF were greater than 0.90, so the diagnosis values ofTSGF, Tg and Tg/TSGF were very high： Tg/TSGF〉Tg〉TSGF. Conclusion Joint detection of TSGF and Tg has high value in the diagnosis of thyroid cancer.
出处
《海南医学》
CAS
2013年第15期2266-2268,共3页
Hainan Medical Journal
关键词
肿瘤特异性生长因子
甲状腺球蛋白
甲状腺癌
诊断
Tumor-specific growth factor （TSGF）
Thyroglobulin （Tg）
Thyroid cancer
Diagnosis
