摘要
目的分析慢性肝炎病毒感染者血清中的抗核抗体(ANA)的检测结果并探讨其临床意义。方法采用间接免疫荧光法(IIF)检测220例慢性乙肝患者和105例慢性丙肝患者及80例健康体检者血清中的抗核抗体,同时检测其生化指标。结果220例慢性乙肝患者中ANA的阳性率为16.4%,慢性丙肝患者ANA的阳性率为19%,均高于正常对照组3.7%,并且以低滴度为主,慢性肝炎患者ANA的荧光核型以颗粒型为主。另外ANA阴性的患者和ANA阳性患者ALT、AST数值分别是102.5±56.2 U/L、79.4±51.6 U/L和165.3±82.5U/L、126.7±68.1U/L。差异有统计学意义。结论肝炎病毒感染可诱导以低滴度为主的ANA产生,对病毒性肝炎患者自身抗体的检测及滴度的监测在鉴别诊断及治疗方案的选择中有一定的临床意义。
Objective To detect the serum anti-nuclear antibodies（ANA） and investigate its clinical significance in patients with chronic hepatitis.Methods A total of 220 patients with chronic hepatitis B and 105 patients with chronic hepatitis C and 80 healthy subjects were enrolled.Indirect immuno-fluorescence assay（IIF） was used to detect the serum ANA,while the biochemistry markers were also deteced.Results The positive rate of ANA in 220 patients with chronic hepatitis B was 16.4%,the rate in 105 patients with chronic hepatitis C was 19%.Both rates were higher than it in control group（3.7%）.The ANA granular fluorescence was highest in patients with chronic hepatitis.In addition the levels of ALT,AST of negative antibodies cases and positive antibodies cases were 102.5±56.2U/L,79.4±51.6U/L and 165.3±82.5U/L,126.7±68.1U/L respectively.The difference between the two groups was statistically significant.Conclusion Hepatitis virus infection can induce the body producing a varivety of low titre ANA,which may play a certain role in hepatitis differential diagnosis and treatment.
出处
《实验与检验医学》
CAS
2013年第4期364-366,共3页
Experimental and Laboratory Medicine
关键词
抗核抗体
慢性病毒性肝炎
自身免疫
Anti-nuclear antibodies
Chronic viral hepatitis
Autoimmune
