摘要
目的通过测定特发性血小板减少性紫癜（ITP）患儿血清中白细胞介素-6（IL-6）、白细胞介素-18（IL-18）和γ-干扰素（IFN-γ）的含量变化，探讨IL-6、IL-18和IFN-γ在ITP的发病机制中的作用。方法选择ITP急性发作期患儿40例（急性组），经治疗后处于缓解期的患儿35例（缓解组），另选择30名健康儿童作为对照（对照组），采用酶联免疫法（ELISA）检测血清IL-6、IL-18和IFN-γ水平变化，并进行统计学分析比较。结果ITP患儿血清IL-6、IL-18和IFN一叮水平急性期组明显高于缓解期组和对照组，缓解期组亦高于对照组，差异均有统计学意义（P均〈0．05）。结论IL-6、IL-18和IFN-γ可能均参与了ITP的发病机制，通过测定血清IL-6、IL-18和IFN-γ水平可以用来判断ITP的病情和预后。
Objective To study the content changes of serum IL-6, IL-18 and IFN-γin childrenwith idiopathic thrombocytopenic （ITP）, and to investigate the role pathogenesis of IL-6, IL-18 and IFN-γMethods Active group （n = 40）and remission group （n = 35 ）with ITR were picked up, and 30 healthy children served as normal controls. IL-6, IL-18 and IFN-γlevels were measured by ELISA, and the results were compared. Results The serum levels of IL-6, IL-18 and IFN-γ in children with active group were markedly higher than those in remission group and healthy controls, and the serum levels of IL-6, IL-18 and IFN-γin remission group were markedly higher than those in healthy controls （P 〈 0. 05）. Conclu- sions IL-6, IL-18 and IFN-γmaybe involved in the pathogenesis of ITP. Determination of IL-6, IL-18 and INF-γlevels can be used to judge the ITP＇ s condition and prognosis.
出处
《中国实用医刊》
2013年第15期54-56,共3页
Chinese Journal of Practical Medicine
