摘要
目的:探讨慢性心功能不全患者血清脂肪因子Chemerin的变化及其临床意义。方法:52例慢性左心功能不全(射血分数EF<45%)患者,以年龄、性别和有无糖尿病史1∶1匹配选取心功能正常患者作为非心衰对照组,26例健康人群为正常对照组,检测体质指数、NT-proBNP等临床及生化指标,ELISA方法检测血浆Chemerin和肿瘤坏死因子α(TNF-α)水平,进行对比研究。结果:心衰患者血浆Chemerin水平较非心衰患者(P<0.001)及正常对照组(P<0.001)明显升高,且随心衰加重而明显升高,多元回归分析显示甘油三酯(r=0.270,P=0.021)、HOMA-IR(r=0.319,P=0.005)、体质指数(r=0.250,P=0.029)、肿瘤坏死因子-α(r=0.348,P=0.003)是影响Chemerin水平的相关因素。结论:Chemerin不仅参与肥胖和代谢综合征的内分泌调节,亦通过参与免疫炎症反应,在心力衰竭的发生发展中发挥重要作用。
Objective： To compare plasma Chemerin levels in patients with chronic heart failure（CHF） and in control subjects, and assesse the association of plasma Chemerin with body composition and metabolic parameters in these subjects.Methods： Serum Cbemerin and Tumor Necrosis Factor- α （TNF- α ） levels were measured by ELISA in 52 patients with CHF and in 52 age, tender, diabetes-history matched controls with cardiovascular disease but normal heart function, and in 26 healthy volunteers.Furthermore, the association between chemerin and NT-proBNP, TNF-α as well as metabolism markers were studied. Results： Plasma Chemerin levels were found to be markedly increased in patients with CHF as compared with patients without CHF and normal controls（P〈0.001）. Multiple regression analysis showed that TG（r=0.270, P=0.021）, body mass index（r=0.250, P=0.029）, HOMA-IR（r=0.319, P=0.005） and TNF-α （r=0.348, P=0.003） were independently related factors influencing plasma Chemerin levels.Conclusion： The present work indicates the potential role of Chemerin in the pathogenesis of chronic heart failure through the immune response.
出处
《中外医学研究》
2013年第22期1-4,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
广东省自然科学基金项目(编号:S2011040001711)
