摘要
目的探讨非酒精性脂肪肝联合应用还原型谷胱甘肽、左卡尼汀治疗前后患者肝功能及血脂变化情况。方法选取60例非酒精性脂肪肝患者,随机分为观察组和对照组,各30例。观察组在常规治疗基础上联合应用还原型谷胱甘肽1.2g、左卡尼汀3.0g,1次/d,对照组在常规治疗基础上单纯应用还原型谷胱甘肽1.2g,1次/d;均连续治疗14d,比较两组治疗前后肝功能及血脂水平改善情况。结果两组治疗14d后,肝功能ALT、AST指标较治疗前均明显降低,差异有统计学意义(均P<0.05);两组治疗后血脂水平较治疗前均下降:观察组治疗14d后血清TG为1.34mmol/L、TC4.56mmol/L,治疗前TG3.28mmol/L、TC8.01mmol/L,前后差异明显,且有统计学意义(P均<0.05),而对照组治疗14d后血清TG2.11mmol/L、TC4.98mmol/L,治疗前血清TG3.09mmol/L、TC97.23mmol/L,治疗前后下降不明显,差异无统计学意义(P均>0.05)。结论还原型谷胱甘肽联合左卡尼汀治疗非酒精性脂肪肝可较好改善肝功能和血脂水平,值得临床推广和应用。
Objective To explore the combined application of nonalcoholic fatty liver was also reduced glutathione,before and after L-carnitine treatment function and the changes of blood lipid in patients with liver disease.Methods 60 patients with nonalcoholic fatty liver patients,randomly divided into observation group and control group,each of 30 cases,.The observation group in the conventional treatment based on the combined application of glutathione 1.2 g,L-carnitine 3.0 g,1 /d,the control group in the conventional treatment on the basis of the simple application of the glutathione 1.2 g,1 times /d;treated continuously for 14 d,compared two groups before and after treatment of hepatic function and blood lipid level to improve the situation.Results Of the two groups after the treatment of 14 d,ALT,AST and liver function parameters were significantly lower than that before treatment,the difference was statistically significant（all P 0.05）;the two group after treatment than before treatment decreased lipid levels：the observation group after treatment for 14 d serum TG was 1.34 mmol/L,TC 4.56 mmol/L,TG 3.28 mmol/L,TC 8.01 mmol/L before and after treatment,significant difference,and there was statistical significance（P 0.05）,while the control group 14 d after treatment,serum TG 2.11 mmol/L TC 4.98 mmol/L,serum TG,TC 97.23 mmol/L and 3.09 mmol/L before treatment,after treatment decreased significantly,no significant difference（P0.05）.Conclusion Glutathione combined with Levocarnitine in the treatment of nonalcoholic fatty liver disease can improve the liver function and blood lipid levels,is worth the clinical promotion and application.
出处
《当代医学》
2013年第22期5-6,共2页
Contemporary Medicine
