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持续正压通气联合卡托普利、硝苯地平治疗重度阻塞性睡眠呼吸暂停低通气综合征合并高血压疗效观察 被引量：5

Clinical observation of continuous positive airway pressure combined with captopril and nifedipine in the treatment of patients with severe OSAHS accompanied with hypertension.
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摘要 目的观察持续正压通气(CPAP)联合卡托普利、硝苯地平对重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者高血压的影响。方法选取重度OSAHS合并高血压患者66例,随机分为对照组及CPAP治疗组各33例。对照组患者予以卡托普利与硝苯地平药物治疗8周,CPAP治疗组患者在卡托普利与硝苯地平治疗的基础上加用CPAP治疗4周。两组分别于治疗前和治疗后同时测量22:00,2:00,6:00的收缩压和舒张压。结果两组患者在22:00,2:00时间点收缩压与舒张压降至140/90的有效率无明显差异(P>0.1,P>0.1)。对照组分别为(78.8%,63.6%)治疗组分别为(75.6%,60.6%);在6:00时治疗组的有效率(75.6%)高于对照组的有效率(51.5%),差异有统计学意义(0.025<P<0.05)。治疗组的总有效率(76.7%)高于对照组总有效率(52.1%),差异有统计学意义(P<0.05)。结论 CPAP联合卡托普利、硝苯地平能有效控制重度OSAHS患者的高血压,效果优于单纯药物治疗组。 Objective To investigate the effect of continuous positive airway pressure （CPAP） combined with captopril and nifedipine on severe obstructive sleep apnea hypopnea syndrome （OSAHS） patients with hypertension. Methods Sixty-six patients with severe OSAHS accompanied with hypertension were randomly divided into control group and CPAP group. In control group, the patients underwent captopril and nifedipine treatment for 8 weeks, while in CPAP group, extra CPAP treatment was applied concurrently for 4 weeks. Systolic and diastolic blood pressures were meas ured at 22：00, 2：00, 6：00 respectively. Effective rate and blood pressure changes before and after the treatment between the two groups were compared. Results The effective rates in both groups showed no significant differences at 22：00 （ Ctrl 78.8% ; CPAP 75.6% ） and 2：00 （ Ctrl 63.6% ; CPAP 60.6% ） （ P 〉 0. 1, P 〉 0. 1 ）. However, effec tive rate in CPAP group was significantly higher （75.6%） than that of control group （ 51.5 % ） at 6：00 （0. 025 〈 P 〈 0.05）. Total effective rate in CPAP group （76.7%） was higher than that of control group （52. 1% ） （P 〈0.05）. Conclusion CPAP combined with Captopril and nifedipine can effectively control hypertension in severe OSAHS pa tients and the total effective rate is higher than oral medication alone.
作者 杨嵘 宗涛 孙亚男 陆金发
机构地区 青岛市城阳区人民医院耳鼻咽喉科
出处 《山东大学耳鼻喉眼学报》 CAS 2013年第3期10-12,共3页 Journal of Otolaryngology and Ophthalmology of Shandong University
关键词 阻塞性睡眠呼吸暂停低通气综合征 持续气道正压通气 高血压 卡托普利 硝苯地平 临床观察 Key words：Obstructive sleep apnea hypopnea syndrome Continuous positive airway pressure Hypertension Captopill Nifedipine Clinical observation
分类号 R766.7 [医药卫生—耳鼻咽喉科]
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参考文献12

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山东大学耳鼻喉眼学报
2013年 第3期

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