摘要
目的通过对118例糖尿病(DM)和糖尿病肾病(DN)患者尿液中足细胞标志蛋白(PCX)及肾功能指标的检测和分析,探讨PCX在糖尿病患者早期肾功能损害中的诊断价值。方法采用免疫比浊法定量检测各组患者和健康者尿液中PCX水平,同时检测所有受试者血液中常用肾功能指标,并对结果进行统计学分析比较。结果患者尿液中PCX与血中胱抑素C(Cys C)、肌酐(Cr)、尿素氮(BUN)、尿微量清蛋白(mAlb)水平呈正相关,且随血糖水平升高,以上指标均有上升趋势,DM、DN组尿液中PCX水平较对照组明显升高,差异有统计学意义(P<0.05)。DM组患者PCX的异常检出率明显高于其他几项指标;DM组PCX异常检出率为18.3%,DN组为70.7%,二者比较,差异有统计学意义(P<0.01)。结论 PCX在DM早期肾功能损害中具有较好的诊断价值。
Objective To explore the diagnostic value of foot cell marker protein podocalyxin（PCX） in early renal function damage of diabetic patients by detecting urine PCX,and analyzing and comparing the renal function indexes in 118 cases of diabetes mellitus（DM） and diabetic nephropathy（DN）.Methods The immunoturbidimetry method was adopted to quantitatively detect the urine PCX level in various groups and the healthy crowd and the common renal function indexes were detected.The results were conducted the statistical analysis and comparison.Results The urine PCX level was positively correlated with the levels of blood CysC,Cr,BUN and mAlb,moreover,with the increase of blood glucose level,the above indexes showed the rising trend.The PCX level in DM group and DN group increased obviously than that in control group（P0.05）.The abnormal detection rate of PCX in the DM group was significantly higher than that of other indexes,the positive rate reached 18.3%,there was statistical difference compared with the control group（P0.05）.The positive rate of PCX in the DN group was 70.7%%,statistical difference existed compared with the normal control group（P0.01）.Conclusion PCX has better diagnostic value in early renal function damage of DM.
出处
《现代医药卫生》
2013年第13期1948-1949,共2页
Journal of Modern Medicine & Health
关键词
糖尿病
肾
损伤
早期诊断
糖尿病肾病
足细胞标志蛋白
Diabetes mellitus
Kidney/injuries
Early diagnosis
Diabetic nephropathies
Podocalyxin
