摘要
目的:研究牡荆素对实验性心肌缺血的作用。方法:采用冠脉结扎致犬急性心肌缺血模型,检测心肌的缺血程度和梗死范围以及血浆中乳酸脱氢酶(LDH)、肌酸激酶(CK)的含量;采用大鼠血瘀证模型,检测血液流变学指标;采用大鼠血栓模型,检测血栓干重及湿重。结果:牡荆素4,2,1mg/kg可显著减小犬心肌的缺血范围和梗死范围,同时不同程度地降低血浆中LDH及CK的异常增高;牡荆素6,3,1.5mg/kg可降低血瘀证模型中全血及血浆粘度值,增加红细胞的变形能力;另外,牡荆素6,3mg/kg可明显减轻血栓的干重,从而抑制血栓形成。结论:牡荆素具有良好的抗心肌缺血作用,其作用可能与抑制缺血心肌的梗死体积、降低全血及血浆粘度、提高RBC变形能力、抑制血栓形成等有关。
Objective： To study pharmacodynamics effects of vitexin on experimental myocardial ischemia.Methods： On coronary artery ligation induced dog acute myocardial ischemia models,we observe ischemia level and infarcted area,detect the contents of LDH,CK in serum;on rat blood stasis models,we detect hemodynamic indexes;on rat thrombosis models,we measure the dry weight and wet weight of thrombus.Results： Vitexin 4,2,1mg/kg significantly reduced myocardial infarct size,decreased the contents of LDH,CK in serum in different degrees;vitexin 6,3,1.5mg/kg attenuated the viscosity of blood and plasma,increased erythrocyte deformation ability;vitexin 6,3mg/kg markedly reduced the dry weight of thrombus,thus inhibited thrombosis.Conclusion： The significant protective effect against myocardial ischemia injury which exhibited by vitexin may related to its reducing the blood and plasma viscosity,improving the ability of RBC deformation,inhibiting thrombosis,etc.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2013年第1期44-47,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
科技部中小企业技术创新基金,编号:06CZ3401023
关键词
牡荆素
心肌缺血
冠脉结扎
血瘀证
血栓证
vitexin（牡荆素）
myocardial ischemia
coronary artery ligation
stagnation of blood
thrombosis
