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树突状细胞参与免疫调节的相关受体及其介导的信号转导通路研究进展 被引量：10

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摘要 树突状细胞(DC)是体内最重要的抗原递呈细胞(APC),具有摄取、处理和提呈抗原至T细胞的功能。DC通过其模式识别受体(PRR)能够识别区分不同类别的病原体,PRR与病原相关分子模式(PAMP)相结合,诱导适应性免疫反应。DC表达的PRR主要包括:Toll样受体(TLR)、C型凝集素受体(CLRs)、NOD样受体(NLR)等。这些受体可以通过启动信号转导通路参与免疫调节。现就DC参与免疫调节的主要相关受体及其介导的信号转导通路研究进展进行综述。
作者 盛康亮 张玲玲 魏伟
机构地区 安徽医科大学临床药理研究所
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2013年第9期997-1000,共4页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金(30973543 31100640 81173075) 安徽省自然科学基金(11040606M195)
关键词 树突细胞 抗原提呈细胞 模式识别受体 病原相关分子模式 免疫调节 信号转导通路
分类号 R392.12 [医药卫生—免疫学]
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同被引文献108

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细胞与分子免疫学杂志
2013年 第9期

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