吡喃阿霉素膀胱内灌注预防浅表性膀胱癌术后复发被引量：35

Intravesical instillation of pirarubicin in the prophylaxis of local recurrence after resection of the superficial bladder cancer

原文传递

导出

摘要目的　评价吡喃阿霉素 (THP)膀胱内灌注预防浅表性膀胱癌术后复发的疗效和安全性。　方法　对 45例浅表性膀胱癌患者行经尿道膀胱肿瘤电切术 (TURBt)或膀胱部分切除术 ,术后定期应用THP(4 0mg/ 40ml)膀胱内灌注 ,每次药物在膀胱内保留 30min。　结果　 45例患者随访 9～ 12个月 ,无肿瘤复发 44例 (97.8% ) ,复发 1例。未见有全身性药物不良反应 ,仅 2例膀胱灌药后出现短时间轻度膀胱刺激症状。　结论　THP膀胱内灌注预防浅表性膀胱癌术后复发疗效满意 ,病人耐受性好。 Objective To evaluate the intravesical instillation of pirarubicin (THP) after resection of superficial bladder cancer. Methods In 45 patients after transurethral resection of the superficial bladder cancer or partial cystectomy,intravesical instillation of THP was given once a week for 8 weeks and then once a month until one year after surgery.The dose of THP was 40mg dissolved in 40ml of 5% glucose solution and retained in the bladder for 30 minutes.The patients have been followed up for 9 to 12 months. Results 44 of the 45 patients have been free from the tumor (97.8%).Tumor recurrence occurred only in 1 patient 6 months after the initial surgery.Transitory bladder irritation was noted only in 2 cases.No systemic side effect has been observed. Conclusions Intravesical instillation of THP has been effective against local recurrence of superficial bladder cancer with least side effects.

作者王翔张元芳瞿连喜丁强王忠

机构地区复旦大学医学院附属华山医院泌尿外科

出处《中华泌尿外科杂志》 CAS CSCD 北大核心 2000年第8期467-469,共3页 Chinese Journal of Urology

关键词吡喃阿霉素浅表性膀胱癌复发预防膀胱内灌注 Bladder neoplasmas Carcinoma Perfusion

分类号 R737.14 [医药卫生—肿瘤]

引文网络
相关文献

参考文献9

1AkazaH,NiijimaT,HisamatsuT ,etal.Comparativeinvestigationonuseof (2"R) 4 O tetrahyhropyranyl adriamycinandadriamycinasintravesicalchemotherapyforsuperficialbladdertumors[].Urolo gy.1988
2KobayashiM,SugayaY,YuzawaM ,etal.Appropriateintravesicalretentiontimeofpirarubicinconcentrationbasedonitslevelintumortissue,anti tumoreffectandsideeffectinintravesicalinstillationtherapyforbladdertumor[].GanToKagakuRyoho.1998
3Kuroda K,Ishii N,Fukasawa K,et al.Short-term intravesical instillation of pirarubicin ( THP ) in prophylactic treatment after transurethral resection of superficial bladder tumor[].Hinyokika Kiyo.1998
4Lamm DL.Prophylaxis for recurrent transitional cell carcinoma[].Urology.1991
5McCabe RP,Lamm LD,Hasrel MV,et al.A diagnostic-prognostic test for bladder cancer using a monoclonal antibody-based enzymelinked immunoassay for detection of urinary fibrin(ogen) degradation products[].Cancer Research.1984
6Muishina T,Watanabe H,Fujiwara T,et al.Therapeutic use of mitomycin C bladder instillation: comparative study of bladder instillation therapy for low stage bladder tumors using eight anticancer drugs.In: Mitomycin Current Impact on Cancer Chemotherapy.1st. Ed. Excerpta Medica Co[].Amsterdam.1982
7Mishina T,Watanabe H,Kobayashi T,et al.Absorption of anticancer drugs through bladder epithelium[].Urology.1986
8Aikawa K,Irisawa C,Muraki O,et al.Postoperative intravesical instillation of THP for superficial bladder tumor: clinical results of prophylactic effects on the recurrence[].Gan To Kagaku Ryono.1992
9Nakagawa S,Kojima M,Nakao M,et al.Fluorescence microscopic study on absorption of adriamycin through the rat bladder epithelium[].Tohoku Journal of Experimental Medicine.1987