摘要
目的观察阿托伐他汀对原发性高血压患者血压变异性的影响。方法 186例原发性高血压患者随机分为阿托伐他汀组(96例)和对照组(90例),对照组单纯使用降压药物,阿托伐他汀组在降压药物基础上加用阿托伐他汀20 mg/d治疗,疗程6个月,通过动态血压监测比较两组治疗前后血压变异性的差异。结果治疗6个月后,两组的24 h收缩压的变异性和舒张压的变异性、日间收缩压的变异性和舒张压的变异性、夜间收缩压的变异性和舒张压的变异性均较治疗前明显改善(P<0.05),阿托伐他汀组较对照组改善更明显(P<0.05)。结论阿托伐他汀能改善高血压患者的血压变异性。
Objective To observe the effects of atorvastatin on blood pressure variability in patients with essential hypertension. Methods One hundred and eight patients with essential hypertension were ran-domly divided into two groups： atorvastatin group （96 cases） and control group （90 cases）. Atorvastatin group was treated with antihypertensive drugs plus addition of atorvastatin （20 mg/d） treatment, control group was using antihypertensive drugs. After 6 months＇ treatment, blood pressure variability by ambulatory blood pressure monitoring were compared. Results After 6 months of treatment, the variability of 24-hour systolic blood pres-sure and diastolic blood pressure variability, the variability of daytime systolic blood pressure and diastolic blood pressure, the variability of the night systolic blood pressure and diastolic blood pressure of the two sets improved significantly （ P 〈 0. 05 ）. Atorvastatin group, compared with the control group, improved significant- ly （P 〈 0. 05 ）. Conclusions Atorvastatin can improve blood pressure variability in hypertensive patients.
出处
《新医学》
2013年第6期378-381,共4页
Journal of New Medicine
基金
深圳市宝安区科技局立项课题(2012208)
关键词
原发性高血压
阿托伐他汀
血压变异性
靶器官损害
Essential hypertension
Atorvastatin
Blood pressure variability
Ambulatory bloodpressure
