摘要
目的观察研究表皮生长因子受体(EGFR)、雌激素(ER)、E-Cadherin在乳腺癌中的表达及其临床意义。方法应用免疫组织化学检测77例乳腺癌组织中EGFR、ER、E-Cadherin的表达。结果 77例乳腺癌中,EGFR、ER、E-Cadherin的阳性表达率分别为29.9%(23/77)、70.1%(54/77)、94.8%(73/77)。ER与患者年龄有统计学意义(P<0.05)。结论 ER、E-Cadherin在乳腺癌组织中的高表达与乳腺癌的发生发展密切相关,多种标志物的联合检测可以为乳腺癌的诊疗和评估预后提供新的方法和思路。
Objective To observe the expression and significance of EGFR,ER and E-Cadherin in breast cancer. Methods Seventy-seven specimens of breast cancer were studied. The expressions of EGFR,ER and E-Cadherin in breast cancer were detected by using immunohistochemical method. Results In 77 specimens of breast cancer, the positive expression rate of EGFR, E R and E-Cadherin was respectively 29.9% （23/77）, 70.1% （54/77）, 94.8% （73/77）. The positive expression rates of ER had statistically relationship with age of patients （P 〈 0.05）. Conclusion Overexpressions of EGFR,ER and E-Cadherin are closely related with the progression of breast cancer, Which provide diagnosis, treatment and evaluating prognosis of breast cancer with new methods and ideas.
出处
《中国现代医生》
2013年第20期30-31,共2页
China Modern Doctor
