摘要
目的采取措施对患有严重ABO溶血病的新生儿，静脉输注大剂量的丙种球蛋白与坏死性小肠结肠炎（NEC）发病的关系进行有效性研究。方法从医院收治的新生儿ABO溶血病患者中选取100例，其中男58例，女42例，他们的年龄在1个月至1岁之间。按照数字表的形式随机将这些患者划分成对照组与观察组，每一组有50例患者。对于对照组主要采取常规性治疗的方法。而对于观察组主要在常规性治疗的基础上给予大剂量的丙种球蛋白（IVIG）治疗。利用统计学理论对两组患者的临床疗效与静脉输注大剂量的丙种球蛋白与坏死性小肠结肠炎的关系进行系统性研究。（P〈0．05）。结果经过一段时间的治疗与护理，观察组患者在治疗前血红总胆红素水平较高的状态，黄疸消退的时间少于对照组患者。而观察组中有10例被诊断为坏死性小肠结肠炎，对照组中有2例被诊断为坏死性小肠结肠炎。经过手术与药物治疗，有1例患儿死于大面积的小肠坏死，2例死于短肠综合征。结论新生儿ABO溶血病静脉用大剂量丙种球蛋白与坏死性小肠结肠炎具有一定的相关性，但丙种球蛋白治疗新生儿ABO溶血病具有良好的临床疗效。
Objective To explore the association of high-dose intravenous gamma globulin with necrotizing enterdcolitis in the treatment of ABO hemolytic disease of the newborn. Methods 1 00 cases of ABO hemolytic disease of the newborn who had been treated in our hospital were selected. 58 were male and 42 were female and they aged between one month to one year. According to the digital form, the infants were randomly divided into a control group and a study group, 50 for each group. The control group received routine treatment; while the study group received high-dose intravenous gamma globulin in addition to routine treatment. The clinical efficacy of the therapy and the association of high-dose intravenous gamma globulin with necrotizing enterocolitis were anaalyzed by using statistical theory. Results After a period of treatment and nursing, the total bilirubin level was at higher baseline level in the study group, and time to jaundice disappearance was shorter in the study group than in the control group. Necrotizing enterocolitis was diagnosed in 10 infants in the study group and in 2 in the control group. After surgical and medical treatment, one infant died of severe intestinal necrosis and 2 died of short bowel syndrome.Conclusions Intravenous high-dose gamma globulin has certain association with necrotizing enterocolitis in the treatment of ABO hemolytic disease of the newborn; however, it has a better clinical efficacy.
出处
《国际医药卫生导报》
2013年第15期2381-2383,共3页
International Medicine and Health Guidance News
