替米沙坦对大鼠围术期心肌梗死心肌细胞凋亡的影响被引量：1

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摘要目的探讨术前应用替米沙坦对大鼠围术期心肌梗死心肌细胞凋亡的影响。方法 12周高脂饮食饲养建立大鼠动脉粥样硬化模型,随机分为替米沙坦组和对照组各20只。替米沙坦组术前1周连续灌胃替米沙坦给药[10 mg/(kg·d)],对照组则以生理盐水灌胃,均通过主动脉内注射月桂酸钠方法建立围术期心肌梗死模型,术后24 h处死大鼠。两组均于建模前后分别测定TC、LDL-C、一氧化氮合酶(NOS)及肌钙蛋白I(cTnI)含量,术后行HE染色观察髂动脉粥样硬化形成情况、心肌微血栓形成率及TUNEL染色观察心肌细胞凋亡率。结果建模后,替米沙坦组和对照组的微血栓形成率分别为(16.6±1.57)%、(16.34±1.02)%,两组比较无统计学差异(P>0.05);替米沙坦组和对照组的凋亡指数分别为(1.15±0.16)%、(2.10±0.17)%,血清NOS浓度分别为(42.58±1.69)、(21.83±1.72)IU/mL,两组比较均有统计学差异(P<0.05或<0.01)。结论术前应用替米沙坦能够有效降低围术期心肌梗死后心肌细胞凋亡率。

作者任宁杜纪兵丛洪良陈树涛郭玉军陈闽荔

机构地区天津市胸科医院

出处《山东医药》 CAS 2013年第25期28-30,共3页 Shandong Medical Journal

关键词围术期心肌梗死血管成形术经腔经皮冠状动脉细胞凋亡大鼠

分类号 R542.2 [医药卫生—心血管疾病]

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