摘要
目的探讨微创手术和开颅手术治疗高血压性脑出血(HIH)的临床效果。方法选择我院2009年3月至2012年5月收治的82例HIH患者的临床资料,其中,43例患者采用了微创手术(观察组),39例患者采用传统开颅手术(对照组),比较两组患者的血管紧张素系统相关指标和3d内血压的变化情况。结果术后3d,观察组患者的肾素、血管紧张素Ⅱ及醛固酮分别为(1.1±0.2)μg/(L·h)、(56.7±12.0)ng/L、(119.2±15.6)ng/L,而对照组分别为(2.1±0.6)μg/(L·h)、(77.4±12.5)ng/L、(150.3±22.4)ng/L,两组比较差异均有统计学意义(t值分别为6.74、8.93、5.61,P均〈0.05)。观察组患者术前及术后1、2、3、天的收缩压分别为(188±12)、(166±10)、(153±9)、(145±9)mmHg,而对照组患者分别为(189±17)、(183±16)、(179±15)、(168±15)mmHg,两组比较差异有统计学意义(F组内=19.41,P〈0.05;F组间=21.33,P〈0.05;F交互=17.56,P〈0.05),且观察组收缩压变化较对照组稳定。结论微创手术治疗HIH,可有效控制患者收缩压水平,患者术后恢复快,预后较好。
Objective To investigate the clinical efficacy of minimally invasive surgery for hypertensive intracerebral hemorrhage (HIH). Methods retrospectively analyzed the clinical data of 82 patients with HIH from March 2009 to May 2012 ,of 43 patients in the observation group with minimally invasive surgery and 39 cases were treated with traditional eraniotomy in control group. Comparing the two groups of patients with angiotensin system related indexes and 3 d internal pressure. Results The renin,angiotensin II and aldosterone of observation group were (1.1 ±0.2) μg/(L · h),(56.7 ± 12.0 ) ng/L and (119.2 ± 15.6) ng/L respectively,while in control group were (2. 1 ±0. 6) μg/( L ± h), (77.4 ± 12. 5 ) ng/L and ( 150. 3 ± 22.4)ng/L respectively,there was a significant difference compared with the control group (t = 6. 74,8.93,5.61, respectively,P 〈 0.05 ). The systolic blood pressure (SBP) preoperative and postoperative 1,2,3 days of observed group were ( 188 ± 12) mm Hg, ( 166 ± 10) mm Hg, ( 153 ± 9) mm Hg, ( 145 ± 9) mm Hg, while of control group were ( 189 ± 17) mm Hg, ( 183 ± 16) mm Hg, ( 179 ± 15) mm Hg, ( 168 ± 15) mm Hg(P 〈 0. 05 ). The difference was statistically significant (F in group = 19.41, P 〈 0. 05 ;F between group = 21.33, P 〈 0. 05 ;F interactive group = 17. 56 ,P 〈 0. 05 ), and the observation changes of SBP were stable than the control group. Conclusion Minimally invasive operation in the treatment of HIH, can effectively control the systolic blood pressure levels. Patients recovered quickly, and of which the prognosis was good.
出处
《中国综合临床》
2013年第8期866-868,共3页
Clinical Medicine of China
关键词
高血压性脑出血
微创手术
开颅手术
肾素
血管紧张素Ⅱ
醛固酮
Hypertensive intracerebral hemorrhage
Minimally invasive surgery
Craniotomy
Renin
Angiotensin II
Aldosterone