摘要
目的探讨2型糖尿病合并早期糖尿病肾病患者的相关危险因素。方法对183例2型糖尿病患者病历回顾性分析,按照患者尿白蛋白排泄率(UAER)水平分为单纯糖尿病组(SDM组,UAER<20μg/min)与早期糖尿病肾病组(EDN组,UAER20～200μg/min),并对两组相关因素进行分析比较。结果 (1)SDM组与EDN组各指标的单因素分析中,患者病程(t=5.56)、BM(It=3.05)、HDL-C(t=7.25)、LDL-C(t=11.36)、HbA1(ct=14.12)有统计学意义(P<0.05);(2)Logistic多因素分析中则有四个因素进入多因素回归模型,分别为病程(OR=1.110,95%CI1.033～1.178)、BM(IOR=1.103,95%CI1.023～1.324)、HDL-C(OR=1.203,95%CI1.027～1.279)及LDL-C(OR=1.873,95%CI1.194～3.210)。结论病程、肥胖、高血脂是2型糖尿病合并早期糖尿病肾病患者危险因素,应早期针对相关危险因素进行防治。
Objective To explore the related risk factors of type 2 diabetic patients with early diabetic nephropathy. Methods Totally 183 type 2 diabetes mellitus patients were enrolled, they were randomly divided into simple diabetes mellitus group （SDM group,UAER〈20 μg/min） and early diabetic nephropathy group （EDN group, UAER 20-200μg/min）according to the urinary protein excretion rate （UAER）. Analyze the relevance of the related factors of the two groups. Results （ 1 ） Single factor analysis： The course of disease （t=5.56）, BMI （t=3.05）, HDL-C （t=-7.25）, LDL-C （t= 11.36 ）, HbA 1 c （t=-14.12 ）are significantly different between SDM group and EDN group （P〈0.05） ;（2） There were 4 factors entered last regression model according to mulitiple factor analysis. They were the course of disease （OR=1. 110,95%CI 1.033-1.178）, BMI （OR=1. 103,95%CI 1.023-1.324）, HDL-C （OR=1.203,95%CI 1.027-1.279） and LDL-C （OR=1.873,95%CI 1.194-3.210）.Conclusion Course of the disease, obesity, high blood lipids are the risk factors of type 2 diabetic patients with early diabetic nephropathy. A series of comprehensive measures should be taken early to prevent and control the related risk factors.
出处
《当代医学》
2013年第20期5-6,共2页
Contemporary Medicine
关键词
2型糖尿病
糖尿病肾病
肥胖
高血脂
Type 2 diabetes mellitus
Diabetic nephropathy
Obesity
Dyslipidemia
