摘要
目的:观察六味地黄汤加味联合比卡鲁胺治疗晚期前列腺癌的临床疗效。方法:将符合晚期前列腺癌的门诊及住院患者84例随机分为治疗组42例(口服比卡鲁胺同时加服六味地黄汤加味);对照组42例(单纯口服比卡鲁胺)。结果:持续追踪观察,治疗组PSA缓解率为52%,对照组为40%,两组比较有显著统计学差异(P<0.01);治疗组中位生存期25.2月,对照组18.9月,两组比较有显著统计学差异(P<0.01),中位TTPP(至PSA进展时间)治疗组10.2月,对照组6.3月,两组比较有统计学差异(P<0.01)。结论:六味地黄汤加味联合比卡鲁胺治疗晚期前列腺癌能延长生存期(OS),至PSA进展时间(TTPP)及提高PSA缓解率。
Objective： Observing the curative effect of Modified Liuwei Dihuang Decoction combining with Biealutamide on treating advanced prostatic cancer. Methods： Randomly dividing 84 outpatients and inpatients who was suffering from advanced prostatic cancer into two groups as 42 cases in the treatment group （ oral administration of Modified Liuwei Dihuang Decoction combining with Bicalutamide） and the other 42 cases in the controlled group （oral administration of Biealutamide simply）. Re- sults ： The follow up observation indicated that remission rate of PSA was 52% for the treatment group while 40% for the control group for which there was statistical difference of comparison （ P〈0. 01 ）. The median survival time of patients from the treat- ment group was 35. 2 months while that of the control group was 18. 9 months for which there was statistical difference of com- parison （P〈0. 01 ）. The median TI＇PP （till the time to progression of PSA） of the treatment group was 10. 2 months while that of the control group was 6. 3 months for which there was statistical difference of comparison （ P〈0. 01 ）. Conclusion ： The com- bined medication of Modified Liuwei Dihuang Decoction combining with Bicalutamide on treating advanced prostatic cancer can prolong survival time （OS） and the time to progression of PSA （TTPP） as well as improving the remission rate of PSA.
出处
《四川中医》
2013年第6期95-96,共2页
Journal of Sichuan of Traditional Chinese Medicine
关键词
六味地黄丸
比卡鲁胺
晚期前列腺癌
Liuwei Dihuang Pill
Biealutamide
Advanced prostatic cancer
