摘要
目的:探讨新生儿高胆红素血症对心肌酶活性的影响。方法:选择高胆红素血症的住院新生儿60例作为治疗组,40例同期出生的正常新生儿作为对照组,分别进行胆红素、心肌酶4项(天冬氨酸转氨酶、肌酸激酶、肌酸激酶同工酶和乳酸脱氢酶)、肌钙蛋白T及心电图检测。结果:新生儿胆红素越高心肌酶活性越高,治疗前和治疗后心肌酶活性比较差异有统计学意义(P<0.01)。随着胆红素的降低血清心肌酶活性明显降低,与正常对照组之间差异无统计学意义(P>0.05)。结论:新生儿高胆红素血症能引起心肌酶活性的升高,但不一定造成患儿心肌细胞不可逆损伤,儿科医生在判断黄胆对心肌有无损伤时除进行心电图检查外,还要将心肌酶和肌钙蛋白T列为常规检测项目,避免新生黄胆患儿因心肌损伤而死亡。
Objective： To discuss the myocardial enzyme activity effect on the neonatal hyperbilirubinemia.Methods： Sixty cases with neonatal hyperbilirubinemia as a treatment group,40 cases of the same period replacement of the normal newborn as a control group.AST,CK,CK-MB,LDH,cTnT and ECG values were monitored.Results： The higher the concentration of bilirubin was,the higher enzyme activity was.With the decrease in total bilirubin level,the myocardial creatine phosphate and creatine kimase-MB were also gradually declining.Before and after treatment enzymogram values in the treatment group were compared and there were significant differences（P 0.01）.Bilirubin level was decreased,myocardial enzymes also decreased,which had no differences in the two groups（P 0.05）.Conclusion： Neonatal hyperbilirubinemia can cause rise of myocardial enzymes,but myocardial cells irreversible damages are uncertain.Pediatricians judge harm of neonatal hyperbilirubinemia on cardiac muscle except ECG,myocardial enzyme and TnT should be as routine examination projects to avoid the death of children with neonatal jaundice due to myocardial damage.
出处
《现代医学》
2013年第6期409-411,共3页
Modern Medical Journal
关键词
新生儿
高胆红素血症
心肌酶
心电图
neonate
hyperbilirubinemia
myocardial enzyme
electrocardiograph
