摘要
目的探讨缺血性脑卒中复发的相关危险因素，为其二级预防提供理论依据。方法登记住院治疗的首次缺血性脑卒中患者612例，随访2年的复发情况，根据是否复发分为复发组和无复发组，记录影响脑卒中复发的各种可能因素，采用Logistic回归模型对这些因素进行分析。结果612例患者中，复发90例，脑卒中后2年的总复发率为14．7％。复发组年龄、吸烟、高血压、糖尿病、心房颤动及高同型半胱氨酸（Hey）血症较无复发组明显升高（P〈0．05）；抗血小板药物依从性较无复发组明显降低（P〈0．01）。Logistic多因素分析显示缺血性脑卒中复发的独立危险因素包括年龄、吸烟、高血压、糖尿病、心房颤动及高Hey血症、抗血小板药物依从性与缺血性脑卒中复发相关（OR值=11，14、47．38、53．1I、111．12、53．11、40．98、90．12，均P〈0．05）。结论年龄、吸烟、高血压、糖尿病、心房颤动及高Hey血症、抗血小板药物依从性均为缺血性脑卒中复发的独立危险因素，加强对这些因素的干预有助于预防缺血性脑卒中的复发。
Objective To explore the risk factors of the recurrence of ischemic stroke and to supply theoreti- cal basis for secondary prevention. Methods 612 patients with ischemic stroke were enrolled in the study and they were followed-up for 2 years to record the stroke recurrence. According to whether the recurrent stroke occurred, all the patients were divided into the recurrent group and the non-recurrent group. Logistic regression model was used to ana- lyze the risk factors. Results Of 612 patients ,90 patients suffered from recurrent stroke and the recurrence rate after 2 years was 14.7%. In the recurrent group, age, smoking, hypertension, diabetes, fibrillation atrial history and homo- cysteine level were significantly higher than those in non-recurrent group （ P 〈 0.05 ）, compliance of anti-platelet drugs was significantly lower than that in non-recurrent group （ p 〈 0.01 ）. Multivariate analysis suggested that age, smoking,hypertension, diabetes, atrial fibrillation history, homocysteine level and compliance of anti-platelet drugs were associated with recurrence of ischemic stroke （ OR value = 11.14,47.38,53.11,111.12,53.11,40.98,90. 12, all P 〈 0.05 ）. Conclusion Age, smoking, hypertension, diabetes, atrial fibrillation history, homocysteine level and compliance of anti-platelet drugs are the independent risk factors of recurrent stroke. To enhance the interference of these risk factors are helpful for preventing the recurrence of stroke.
出处
《中国基层医药》
CAS
2013年第14期2081-2083,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
安徽省科技计划项目（08020303069）
关键词
脑血管意外
复发
危险因素
Cerebrovaseular accident
Recurrence
Risk factors
