摘要
目的观察奥沙利铂联合替吉奥方案与FOLFOX4方案治疗晚期直肠癌的近期疗效和不良反应。方法将36例晚期直肠癌患者随机分为观察组和对照组,均化疗至少2个周期,比较近期疗效及不良反应。结果两组有效率比较差异无统计学意义(P>0.05)。不良反应中对照组静脉炎发生率显著高于观察组,且差异有统计学意义(P<0.05)。结论奥沙利铂联合替吉奥方案与FOLFOX4方案治疗晚期直肠癌的疗效相近,但前者具有用药更为方便,耐受性稍好,安全性更好等优点,值得临床一线使用。
Objective To observe the short-term effect and adverse reaction of oxaliplatin combined with S1 and FOLFOX4 regimen in the treatment of advanced rectal cancer.Methods Thirty-six cases of advanced rectal cancer were randomly divided into group observation and the group control,with at least 2 cycles of chemotherapy,the efficacy and adverse reaction were compared.Results The effective rate of the two groups has no significant difference（P＆gt;0.05）.The the incidence of phlebitis in group control was significantly higher than that in group observation,and there was significant difference（P＆lt;0.05）.Conclusion The effect of oxaliplatin combined with S1 and FOLFOX4 regimen on advanced rectal carcinoma are similar,but the former has the advantage of convenient for use,good tolerance,better safety and is worth the clinical first-line use.
出处
《临床医学》
CAS
2013年第4期6-7,共2页
Clinical Medicine
