摘要
目的:探讨妊娠晚期注射乙肝免疫球蛋白(HBIG)对阻断乙肝病毒母婴传播的效果。方法:120例HBsAg、HBeAg均阳性的孕妇纳入研究,将母亲妊娠晚期注射HBIG分为观察组(妊娠晚期从28周开始一次性肌注HBIG 200IU,每间隔4周肌注1次,共3次),妊娠晚期未注射HBIG者作为对照组。根据孕期乙肝病毒脱氧核糖核酸(HBV-DNA)载量分为高风险、低风险和极低风险,胎儿娩出后立即收集脐静脉血进行HBsAg测定。观察孕晚期注射HBIG后对婴儿免疫效果的影响。结果:HBV-DNA高风险的孕妇孕晚期注射HBIG对提高新生儿阻断成功率有帮助,观察组感染率为14.81%,对照组感染率为40.91%,组间比较差异具有统计学意义(P<0.05)。低风险和极低风险观察组感染率分别为13.63%、10.53%,对照组感染率分别为2.0%、13.33%,组间比较差异无统计学意义(P>0.05)。结论:孕期HBV-DNA低风险和极风险孕妇,孕晚期注射HBIG对阻断乙肝病毒母婴传播无明显效果;HBV-DNA高风险的孕妇孕晚期注射HBIG对减少胎儿宫内感染有一定帮助。
Objective： To investigate the effect of antepartum injection of hepatitis B immunoglobulin on blocking the mother-to-infant transmission of HBV. Methods： A total of 120 pregnant women with positive HBsAg and HBeAg were included in this study. The patients were randomly divided into study and control groups, in which each group was divided into high level of HBV-DNA, lower level of HBV-DNA and the lowest level of HBV-DNA subgroups according to the DNA level of HBV in serum. The study group ac- cepted injection of HBIG 200 IU after conception 28, 32 and 36 weeks. Women in the control group were not given HBIG. The cord blood of all newborns was collected for testing HBsAg. Results： The rate of in- trauterine infection was lower after injecting HBIG during antepartum in high level of HBV-DNA sub- group. But there were no differences in the lower level of HBV-DNA group and the lowest level of HBV- DNA group. Conclusion： In pregnant women with higher level of HBV-DNA, injection of HBIG during an- terpartum may reduce the rate of intrauterine infection.
出处
《广西医科大学学报》
CAS
2013年第2期199-201,共3页
Journal of Guangxi Medical University
基金
广西自然科学基金资助项目(No.桂科自0832115)
关键词
孕晚期
乙肝免疫球蛋白
母婴垂直传播
late pregnancy
hepatitis B immunoglobulin
vertical transmission
